virus infections – Communicable Diseases Research

Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?

article

Published on 2023-01-012024-09-02
Journal: Microbes and infection [Category] 대상포진,

A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants

ACE2 및 TMPRSS2를 발현하는 새로 설계된 A549 세포주는 Delta 및 Omicron 변이체를 포함하여 SARS-CoV-2에 매우 관대합니다.

Article

Published on 2022-06-232022-09-11
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] A549 A549 cell A549 cells ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antivirals breakthrough infections can be used Cell coronavirus Critical Culture Delta delta and omicron variants drugs EIDD-1931 Express expressed expressing Factor Host human ACE2 human cell identify Including Infection infection with SARS-CoV-2 inhibit SARS-CoV-2 lack LINE nelfinavir New Nirmatrelvir omicron Omicron variants Permissive Remdesivir respiratory Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serine severe acute respiratory syndrome Coronavirus Spike protein susceptible the SARS-CoV-2 TMPRSS2 transcript transducing transmembrane serine protease transmembrane serine protease 2 variant Viral viral entry virus infections
[DOI] 10.3390/v14071369 PMC 바로가기 [Article Type] Article

Nucleocapsid protein of SARS-CoV-2 is a potential target for developing new generation of vaccine

SARS-CoV-2의 뉴클레오캡시드 단백질은 차세대 백신 개발을 위한 잠재적인 표적입니다

Article

Published on 2022-06-012022-09-11
Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] antibody BALB/c mice Blot correlated COVID-19 patient COVID-19 patients cytokine cytokine production develop disease severity elicited ELISA ELISA assay ELISA assays Escherichia coli expressed IgG antibody IgM antibody immune immune response immune responses immunization immunize immunized immunoreactivity in viral Infection investigated less mice mutations N protein nucleocapsid nucleocapsid protein potentiality Prevent produced Protein purified S protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 variants SARS-CoV-2 virus serum serum antibodies serum antibody specific serum spike glycoprotein Spread the N protein the S protein the SARS-CoV-2 Vaccine Vaccines variants Viral viral infection virus infection virus infections was used were used western blot
[DOI] 10.1002/jcla.24479 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3

SARS-CoV-2 스파이크는 인터페론 조절 인자 3을 표적으로 하여 선천적인 항바이러스 면역을 길항합니다

Cellular and Infection Microbiology

Published on 2022-01-102022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome Analysis antiviral immune response biochemical blocked Cell cells Co-expression analysis control cells Corona virus COVID-19 COVID-19 pathogenesis cytokine Cytokines disease disease severity downstream ectopic expression evade experiment expressing expression expression of SARS-CoV-2 facilitate Factor Genes Host IFN-I IFNβ immunoassay immunoassays indicated infections inhibitor Innate innate immune response Innate immunity interferon interferon regulatory factor IRF3 mechanism NF-κB Pathogenesis Pattern recognition pattern recognition receptor proteasomal degradation Protein remained respiratory RIG-I RIG-I antiviral RNA SARS-CoV-2 SARS-CoV-2 spike Severe Acute Respiratory Syndrome Corona Virus Signaling spike Stat1 stimulated suppressed targeting the SARS-CoV-2 transcription factor type I interferon Viral viral burden Viral RNA virus Virus Disease virus infections
[DOI] 10.3389/fcimb.2021.789462 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

The radiological findings of COVID-19

코로나19의 방사선학적 소견

Review

Published on 2021-12-172022-09-10
Journal: Turkish Journal of Medical Sciences [Category] SARS, 진단, 치료기술,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease Affect Care caused clinician Complication Computed tomography consolidation coronavirus disease COVID-19 COVID-19 pneumonia CT finding CT findings diagnose diagnostic tests disease distribution dysfunction early stage extrapulmonary involvement Fatty liver feature Features gastrointestinal complications GGO GGOs Google Scholar ground glass opacities help imaging incidentally detected indications Inflammation information kidneys less liver dysfunction lobes lower lobes manifestation Manifestations material neurological abnormalities neurological abnormality not limited Novel coronavirus novel coronavirus disease other organs Other Viral Diseases overlapped pancreas Patient patients with COVID-19 performed periphery Pneumonia radiological radiological finding radiologist Radiologists renal dysfunction reported respiratory Respiratory system Result SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection significantly signs the disease Vascular Viral diseases virus infections
[DOI] 10.3906/sag-2106-203 PMC 바로가기 [Article Type] Review

The potential of COVID-19 patients’ sera to cause antibody-dependent enhancement of infection and IL-6 production

COVID-19 환자의 혈청의 잠재력은 감염 및 IL-6 생산의 항체 의존적 향상을 유발합니다.

Article

Published on 2021-12-092022-09-01
Journal: Scientific Reports [Category] SARS, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADE Antibody-dependent enhancement cell line clone cloned coronavirus COVID-19 demonstrated dengue virus evaluate host cell host cells IL-6 immortalized Infection infection with SARS-CoV-2 infections initiated myeloid cell neutralizing antibody other coronavirus other coronaviruses productivity respiratory resulting SARS-CoV-2 SARS-COV-2 infection screened sera severe acute respiratory syndrome Coronavirus severe COVID-19 patient severe COVID-19 patients stimulate susceptibility TMPRSS2 vaccination Vaccine development vaccine trial virus infections
[DOI] 10.1038/s41598-021-03273-0 PMC 바로가기 [Article Type] Article

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다

Research Article

Published on 2021-11-222022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article

The Disappearance of Respiratory Viruses in Children during the COVID-19 Pandemic

COVID-19 팬데믹 기간 동안 어린이의 호흡기 바이러스 소실

Article

Published on 2021-09-102022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 치료기술,

[키워드] absence analyzed childhood circulation COVID-19 declined detect disappearance Diseases Epidemic Face masks FIVE flu Health hospital Immunity Infection Influenza Influenza virus Intervention Italian lack Local macroscopic measure nasopharyngeal sample Nasopharyngeal samples pandemic pandemic spread Patient Public Public health interventions reduce reduction in related diseases respiratory respiratory infections respiratory symptom respiratory symptoms respiratory syncytial virus respiratory virus Respiratory virus infections respiratory viruses rhinovirus RSV serious infection serious infections social distancing social distancing measures spread of COVID-19 spreading susceptibility the epidemic Transmission Viral viral infections viral respiratory infection virus infections viruses were assessed
[DOI] 10.3390/ijerph18189550 PMC 바로가기 [Article Type] Article

COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series

백신 접종 인구의 COVID-19 폐렴: 6가지 임상 및 방사선 사례 시리즈

Case Reports

Published on 2021-08-272022-09-10
Journal: Medicina [Category] MERS, SARS, 변종,

[키워드] advent age age factors be positive case reports caution Chest computed tomography chest pain clinical clinical trial Computed tomography COVID-19 COVID-19 pneumonia COVID-19 vaccines delta variant died disease dose Dyspnea Factor Factors Fever follicular Follicular lymphoma Genetic Hospitalized humans Immunocompromised immunocompromised state lymphoma Mask Masks mild pneumonia moderate one patient pandemic Patient patients performed Pneumonia positive preserved radiological finding related disease representing respiratory rituximab SARS-CoV-2 second vaccination Sery Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown social distancing suggested Swab tested therapy These data Two patient two patients vaccination vaccine immunogenicity variant virus infection virus infections virus mutations worsening
[DOI] 10.3390/medicina57090891 PMC 바로가기 [Article Type] Case Reports

The Anti-SARS-CoV-2 Antibody Response in a Centenarian Woman: A Case of Long-Term Memory?

100 세 여성의 항 -SARS-COV-2 항체 반응 : 장기 기억의 사례?

Case Reports

Published on 2021-08-272022-09-01
Journal: Viruses [Category] MERS, SARS, 진단,

[키워드] absence addressed affected Anti-spike appear Asymptomatic B cell B cell memory B cells Blood cell-ELISA Centenarian classical clinical consequence clinical consequences conditions COVID-19 COVID-19 pandemic described ELISA heterogeneity heterogeneous highest highlight Host immune response IgG immune defense immune memory in vitro in vitro IgG increase in Infection long-term memory low-grade inflammation Manifestations memory memory B cells Mild mortality rate observation Occurrence Older plasma positive potential mechanism produced reached released reported respiratory response responsible SARS-CoV-2 SARS-COV-2 infection Serological testing serum severity specific antibodies specific antibody susceptibility syndrome the SARS-CoV-2 turn virus virus infection virus infections was tested while
[DOI] 10.3390/v13091704 PMC 바로가기 [Article Type] Case Reports