Rapid Determination of SARS-CoV-2 Integrity and Infectivity by Using Propidium Monoazide Coupled with Digital Droplet PCRCommunication Published on 2024-06-032024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] ddPCR Digital droplet PCR negative-chain PCR PMA PMAxx Propidium monoazide SARS-CoV-2 Viral isolation virus infectivity virus integrity [DOI] 10.3390/ijms25116156 PMC 바로가기 [Article Type] Communication
Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro machine learning machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Interferon resistance of emerging SARS-CoV-2 variants새로운 SARS-CoV-2 변이체의 인터페론 내성Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] (Alpha) (Beta) Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Course COVID-19 COVID-19 pandemic Critical driving ENhance exhibited FIVE highlight implication include infections Innate immunity interferon interferon response interferons isolates lethality limit lineages Mutation neutralizing antibody outbreak P.1 Pathogenesis potency responses SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants spike spike mutations subtype the interferon Transmissibility Treatment Vaccine variant variants variants of concern Viral viral gene viral genes viral lineage virus infectivity while [DOI] 10.1073/pnas.2203760119 PMC 바로가기 [Article Type] Article
“Is Omicron mild”? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies"오미크론은 마일드한가"? 세 계보의 돌연변이 환경과 기존 백신 및 치료 항체에 대한 반응으로 이 내러티브 테스트Review Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody conserved convalescent COVID-19 infections Effectiveness Evolution Genome Giant immune immune evasion Immunity infections Lineage mild symptoms monoclonal Mutation narrative neutralization neutralization resistance Neutralizing antibodies neutralizing antibody omicron Omicron lineages Pathogenesis polyclonal Positive selection produced raised Receptor-binding domain reduction in Reinfection reported SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants shown Spike protein tested Testing the receptor-binding domain the spike protein therapeutic triggered Vaccine vaccine effectiveness (VE) Viral viral evolution virus infectivity [DOI] 10.1002/jmv.27749 PMC 바로가기 [Article Type] Review
SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy예방 접종 및 변종: 이탈리아의 Covid-19 진화에 대한 회고 모델Article Published on 2022-07-082022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] absence appearance changes characterized combined effect compartmental model contagious COVID-19 pandemic deaths decreases delta variant develop dominant effective Effects epidemiological Evolution followed by individual induce Infection Italy measure mechanism mechanisms normality omicron Omicron variant pandemic Particular predict Retrospective analysis seasonal variation stability vaccination Vaccine Variability variant Variation virus virus infectivity waning immunity [DOI] 10.1371/journal.pone.0265159 PMC 바로가기 [Article Type] Article
Viral RNA Load and Infectivity of SARS-CoV-2 in Paired Respiratory and Oral Specimens from Symptomatic, Asymptomatic, or Postsymptomatic Individuals무증상, 무증상 또는 무증상 개인의 호흡기 및 구강 표본에서 SARS-CoV-2의 바이러스 RNA 부하 및 감염성Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] anterior nares Asymptomatic Asymptomatic individuals asymptomatic patient asymptomatic patients bodily secretions Care care provider classic close contact collected COVID-19 COVID-19 diagnosis Critical diagnosed with COVID-19 diagnostic diagnostic sensitivity diagnostic testing epidemiological FIVE followed by Frequency Health Health care help individual individuals infection with SARS-CoV-2 Infectious virus Infectivity information initial Isolation load molecular nare nares nasopharyngeal oral patients platform positive individual positive individuals provide quarantine respiratory RNA RT-PCR Saliva saliva specimens Sample Sampling frequency SARS-CoV-2 secretion sensitivity specimen specimens Surveillance Swab swabs symptomatic symptomatic patient Symptomatic patients tested The diagnostic sensitivity understanding viral RNA load virus detection virus infectivity virus isolation was determined [DOI] 10.1128/spectrum.02264-21 PMC 바로가기 [Article Type] Article
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655YIns215KLRS 및 H655Y의 비 RBD 돌연변이에 의한 SARS-CoV-2의 N501Y 부여 마우스 감염성의 장거리 향상Article Published on 2022-06-052022-09-11 Journal: Biology Direct [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Beta changes in cooperation Cross-species transmission disrupt ENhance facilitate flexible Gamma H655Y high infectiousness hosts Impact impacts increase Ins215KLRS insertion Interaction intramolecular interaction less Local mice mouse Mouse infection mouse-adapted strain mutant Mutation N-terminal domain N501Y N501Y mutation NTD omicron Omicron variants peptide Protein RBD Receptor binding Receptor-binding domain resulting rodents SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein suppressed targets the receptor-binding domain variant virus infectivity wild type [DOI] 10.1186/s13062-022-00325-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5SARS-CoV-2 ORF7a는 숙주 인자 SERINC5의 항바이러스 효과를 강력하게 억제합니다Article Published on 2022-05-262022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral effect biogenesis Cell fusion cellular coronavirus 2 counteract evaluated expressed Factor HIV Host Human Human immunodeficiency virus immunodeficiency virus incorporation information inhibit involved ORF7a Protein respiratory restrict retroviruses SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SERINC5 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sphingolipid transmembrane protein turn virion virions virus infectivity while [DOI] 10.1038/s41467-022-30609-9 PMC 바로가기 [Article Type] Article
Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids난잡한 SARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인과 데옥시리보핵산의 상호작용에 대한 특이성에 대한 통찰력Article Published on 2022-04-012022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 치료법, [키워드] activity approximation binding Binding specificity cleft dissect DNA DNA binding DNA/RNA binding protein double-stranded feature inhibitors insight Interaction Local motif multifunctional N-terminal domain non-specific nucleic acid nucleocapsid parameter preference Protein RNA RNA binding protein SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein sequence specificity starting point suggested the N protein therapeutic target thermodynamic thymidine Transcription transcriptional regulatory sequence transcriptional regulatory sequences TRS virus infectivity β-sheet [DOI] 10.1016/j.ijbiomac.2022.01.121 PMC 바로가기 [Article Type] Article