Recombinant OC43 SARS-CoV-2 spike replacement virus: An improved BSL-2 proxy virus for SARS-CoV-2 neutralization assaysBiological Sciences Microbiology Published on 2024-07-082024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] coronavirus HCoV-OC43 mucosal vaccine SARS-CoV-2 virus-neutralizing antibodies [DOI] 10.1073/pnas.2310421121 PMC 바로가기 [Article Type] Biological Sciences Microbiology
Preliminary Study on the Efficacy of a Recombinant, Subunit SARS-CoV-2 Animal Vaccine against Virulent SARS-CoV-2 Challenge in CatsArticle Published on 2023-12-082024-09-05 Journal: Vaccines [Category] update2024, [키워드] cats feline immune response recombinant vaccine SARS-CoV-2 virus-neutralizing antibodies [DOI] 10.3390/vaccines11121831 PMC 바로가기 [Article Type] Article
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial재조합 인터페론 무장 융합 단백질 백신(V-01)을 사용한 SARS-CoV-2에 대한 이종 부스팅의 효능: 무작위, 이중 맹검 및 위약 대조 3상 시험Clinical Trial Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adverse event antibody assigned booster clinical trial common adverse event conducted COVID-19 vaccine COVID-19 vaccines dose double-blind dramatic increase Efficacy elicit eligible fatigue Fever fusion protein groups headache healthy Heterologous heterologous boosting Humoral immunity Identifier Immunity inactivated Inactivated vaccine Inactivated Vaccines Inc injection injection site intention-to-treat principle Malaysia Mild-to-moderate Neutralizing Neutralizing antibodies occurred Older omicron Omicron variant over Pain participant Participants Placebo placebo-controlled primary endpoint Randomized Randomly receive regimen robust Safe SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Events subunit Subunit vaccine Surveillance symptomatic SARS-CoV-2 infection the epidemic titre Trial Trial registration V-01 Vaccine vaccine efficacy variant virus-neutralizing antibodies was measured were assessed [DOI] 10.1080/22221751.2022.2088406 PMC 바로가기 [Article Type] Clinical Trial
Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination자연 SARS-CoV-2 감염 및 Gam-COVID-Vac 백신 접종 후 시험관 내 재활성화된 기억 B 세포의 기능 프로파일링Article Published on 2022-06-212022-09-11 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adenovirus antibody antibody-secreting cells B-cell response circulating comprehensive analysis convalescent patient Convalescent patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients demonstrated elicit frequencies Frequency Gam-COVID-Vac Gam-COVID-Vac vaccine healthcare humoral Humoral immunity immune response immune responses Immunity individual Infection MBC MBCs memory B memory B cell memory B cells natural natural immunity Neutralizing Neutralizing antibodies outperform performed platform Profiling Receptor binding domain recipients robust SARS-CoV-2 SARS-COV-2 infection Serum level serum levels side significantly higher Sputnik V vaccine vaccination variants of SARS-CoV-2 Viral viral antigens virus-neutralizing virus-neutralizing antibodies [DOI] 10.3390/cells11131991 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice andIs Recognized by COVID-19 PatientsSARS-CoV-2 스파이크 수용체 결합 모티프 펩티드는 마우스에서 스파이크 방지 항체를 유도하고 COVID-19 환자가 인식합니다Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 anti-S antibody Antigen available data benefit caused conformational coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 patient domain elicit ELISA expressed Frequency Human human host cell immunized immunized animals immunized mice Infection interact Ligand means Neutralizing neutralizing Abs neutralizing function pandemic penetrate peptide peptide synthesis problems produced Protein RBD RBD domain RBM receptor Receptor binding receptor binding motif Region Research S protein SARS-CoV-2 selected spike spike (S) protein subject the antibody response the disease the S protein Treatment trimeric spike Vaccine Vaccines virus virus-neutralizing antibodies [DOI] 10.3389/fimmu.2022.879946 PMC 바로가기 [Article Type] Article
Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variantsSARS-CoV-2 바이러스 변이체에 대한 백신 유도 전신 및 점막 T 세포 면역Article Published on 2022-05-172022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] absence antibodies B1.351 CD4 CD4 T cell CD4 T cells CD8 T cell CD8 T cells CLARITY conserved COVID-19 vaccine Critical detectable effective Effectiveness elicit epitope Epitopes evade homologous Hospitalization Immunity immunization implication Infection knowledge lack lung immunopathology Lung pathology memory memory T cell memory T cells mucosal neutralized Neutralizing antibodies presence of antibody presence or absence PROTECT Protective protective vaccines provided SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral T cell T cell responses T cells Vaccine variant Viral viral control virus virus-neutralizing antibodies [DOI] 10.1073/pnas.2118312119 PMC 바로가기 [Article Type] Article
Designed SARS-CoV-2 receptor binding domain variants form stable monomers설계된 SARS-CoV-2 수용체 결합 도메인 변이체가 안정적인 단량체를 형성합니다.Article Published on 2022-05-012022-09-11 Journal: Biotechnology Journal [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addressed aggregates antibody antibody assay validation Antigen antigen stability binding domain Cell convalescent sera COVID-19 COVID-19 patient cysteine cysteine residue Deletion enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays eukaryotic systems expression HEK293 homogeneous intrinsic maintenance mammalian cell mammalian cells monomer monomeric Neutralizing antibodies O-glycosylation site produced Protein RBD RBD variant Receptor binding Receptor binding domain Recombinant expression reduce SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2 test sequence serological shown Substitution the SARS-CoV-2 vaccine candidates Vaccine development variant virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1002/biot.202100422 PMC 바로가기 [Article Type] Article
Single-Domain Antibodies Efficiently Neutralize SARS-CoV-2 Variants of Concern단일 도메인 항체가 우려되는 SARS-CoV-2 변이체를 효율적으로 중화Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibodies antibody antibody-based therapies Beta broad spectrum caused concern COVID-19 Delta dimeric drug candidate Evolution of SARS-CoV-2 exhibiting Gamma generate heterodimeric increase in Modification nanobodies neutralization potency neutralized Neutralizing Neutralizing activity Neutralizing antibodies omicron Omicron variants Receptor-binding domain reduced robust S glycoprotein SARS-CoV-2 SARS-CoV-2 S glycoprotein SARS-CoV-2 variant SARS-CoV-2 virus selected sensitivity single-domain antibodies the receptor-binding domain Treatment treatment for COVID-19 variants VHH virus virus variant virus variants virus-neutralizing antibodies VoC were used [DOI] 10.3389/fimmu.2022.822159 PMC 바로가기 [Article Type] Article
Understanding the outcomes of COVID-19 – does the current model of an acute respiratory infection really fit?COVID-19의 결과 이해 – 현재의 급성 호흡기 감염 모델이 정말 적합합니까?Insight Review Published on 2021-12-172022-09-12 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, [키워드] Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody appearance assumption attribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease severity Effect Epidemic Evidence example followed by hepatitis C hepatitis C virus host immune responses immune responses increasingly individual Infection Influenza influenza A influenza A virus instance lack literature review mammalian Neutralizing antibodies occur outcome pathogenic PCR positivity persistence Prolonged proportion protective immunity Reinfection respiratory syncytial virus respiratory syncytial virus influenza A virus respiratory viruses RNA RNA genome RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus understanding virus clearance virus-neutralizing antibodies [DOI] 10.1099/jgv.0.001545 PMC 바로가기 [Article Type] Insight Review
A Novel Double Mosaic Virus-like Particle-Based Vaccine against SARS-CoV-2 Incorporates Both Receptor Binding Motif (RBM) and Fusion DomainArticle Published on 2021-11-052022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 receptor addition Antigen Bacterial clinical development COVID-19 COVID19 CuMVTT-DF displaying domain E. coli fused fusion fusion peptide Health homogeneity IgA IgG antibody independent induce Microscopy mortalities mosaic neutralizing antibody neutralizing epitopes novel pandemic Particle produced RBD RBM receptor binding motif recognizing SARS-CoV-2 SARS-CoV-2 virus scattering subunits Vaccine vaccine candidate Virus-like particle virus-neutralizing antibodies virus-neutralizing antibody VLP was used were used [DOI] 10.3390/vaccines9111287 PMC 바로가기 [Article Type] Article