An insight to the therapeutic potential of algae-derived sulfated polysaccharides and polyunsaturated fatty acids: Focusing on the COVID-19Review article Published on 2022-06-012022-10-05 Journal: International journal of biological macromolecules [Category] 변종, 치료제, [키워드] addition affected Algae candidate Compound coronavirus COVID-19 COVID-19 case Critical Effectiveness fatty Fatty acid Focusing Gut gut microbiome Health immune regulation immune system immunomodulatory activities immunomodulatory property Infection infections intestine Microbiome microbiota modulate modulating modulation Mutation nutritional intervention other organ pandemic Polyunsaturated Polyunsaturated fatty acids Prevent produced Research resources response sulfated polysaccharide sulfated polysaccharides the vaccine therapeutic therapeutic potential these compound Treatment Vaccine viral infections virus virus pathogenesis [DOI] 10.1016/j.ijbiomac.2022.03.063 [Article Type] Review article
Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2게놈 전체의 CRISPR 화면은 ACE2의 변조를 통해 GATA6을 SARS-CoV-2의 프로바이러스 숙주 인자로 식별합니다.Article Published on 2022-04-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 Alpha Alpha variant Analysis anti-SARS-CoV-2 Beta biogenesis candidate cellular clathrin clinical sample clinical samples collected Comparative analysis component COVID-19 pathogenesis CRISPR CRISPR screen Critical data-set elevated facilitate Factor GATA6 Health heparan sulfate Host host gene host genes identify infected individuals Infection KREMEN2 list loss-of-function modulation pathway pharmacological phosphatidylglycerol regulate required SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SETDB1 Spread sulfate target therapeutic interventions therapeutic strategy Transcription transcription factor Transport unique variant variants of concern variants of SARS-CoV-2 viral infectivity virus pathogenesis VoC VOCs wild type Zinc [DOI] 10.1038/s41467-022-29896-z PMC 바로가기 [Article Type] Article
Within-host models of SARS-CoV-2: What can it teach us on the biological factors driving virus pathogenesis and transmission?SARS-CoV-2의 숙주 내 모델: 바이러스 발병 및 전파를 주도하는 생물학적 요인에 대해 무엇을 가르칠 수 있습니까?Editorial Published on 2022-04-012022-09-11 Journal: Anaesthesia, critical care & pain medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Abstract Antiviral treatment driving Factor Host–pathogen interaction Immunity Mathematical modelling virus dynamics virus pathogenesis [DOI] 10.1016/j.accpm.2022.101055 PMC 바로가기 [Article Type] Editorial
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
Evolution of the SARS-CoV-2 spike protein in the human hostArticle Published on 2022-03-042022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] ACE2 binding ACE2 receptor acquisition Alpha Alpha variant B.1.1.7 B.1.351 Beta binding changes in cleavage Combination Cryoelectron microscopy D614G Delta dependent on Evolution examined furin site greater transmissibility human host humans K417N Mutation N501Y Neutralising Antibodies observation omicron receptor receptor ACE2 Receptor binding receptor-binding domains required SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein Spike protein spike trimer stability Substitution the SARS-CoV-2 Transmission variant variant spike variants of concern variants of SARS-CoV-2 viral evolution virus virus pathogenesis [DOI] 10.1038/s41467-022-28768-w PMC 바로가기 [Article Type] Article
Biomimetic Alveolus-on-a-Chip for SARS-CoV-2 Infection RecapitulationResearch Article Published on 2022-02-042022-10-29 Journal: Research [Category] COVID-19, [키워드] alveolar antibody caused Characteristics develop Extracellular matrix human lung in vitro morbidity and mortality organ pandemic pathophysiology physiological platform provide pseudovirus SARS-CoV-2 SARS-CoV-2 pathogenesis severe pneumonia viral infection virus pathogenesis [DOI] 10.34133/2022/9819154 PMC 바로가기 [Article Type] Research Article
COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants EraCOVID-19: 새로운 SARS-CoV-2 변종 시대의 바이러스 병인, 치료 전략 및 백신 설계에 대한 구조적 고려 사항Review Published on 2021-10-012022-09-11 Journal: Molecular biotechnology [Category] MERS, SARS, 변종, 신약개발, 진단, [키워드] antibody approach caused coronavirus COVID-19 creating highlight impacted less novel pandemic public health SARS-CoV-2 SARS-CoV-2 mutations Strategy therapy Tunnel Vaccine Vaccine design variant variants variants of SARS-CoV-2 virus pathogenesis virus variant [DOI] 10.1007/s12033-021-00353-4 PMC 바로가기 [Article Type] Review
Interplay between SARS‐CoV‐2‐derived miRNAs, immune system, vitamin D pathway and respiratory systemSARS-CoV-2 유래 miRNA, 면역계, 비타민 D 경로 및 호흡기계 간의 상호작용Original Article Published on 2021-06-222022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] analysed Analysis bioinformatics biological processe biological processes China contributing to coronavirus death develop Disease progression Evidence expression level functional enrichment Functional enrichment analysis Genes Genome help Host identify immune pathway immune pathways immune system intensity involved many cases mature miRNA mature miRNAs mechanism Mild miRNA miRNAs molecular New coronavirus pandemic Pathogenesis pathway Pathways precursor predict predicted recognize regulatory element regulatory region Research respiratory Respiratory system RNAseq RNAseq data SARS‐CoV‐2 SARS‐COV2 target gene Target genes the disease therapeutic target Viral viral miRNAs virus virus genome virus pathogenesis Vitamin D vitamin D pathway [DOI] 10.1111/jcmm.16694 PMC 바로가기 [Article Type] Original Article
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort프랑스 COVID 코호트의 입원 환자에서 SARS-CoV-2 바이러스 역학 및 사망률과의 연관성 모델링422 Published on 2021-02-232022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis analyzed association average build characterization chronic pulmonary disease Cohort collected coronavirus COVID death disease Effect effective Evolution French Gender hazard ratio High-risk patients Hospital admission hospitalized patient hospitalized patients identify independent infected cells information joint male mathematical mathematical model median median time modeling Mortality mortality rate Multivariate analysis nasopharyngeal viral occur older patients outcome Patient pharmacological intervention predict predicted prolonged viral shedding pulmonary disease reduce reduction respiratory risk factor Risk factors risk of death SARS-CoV-2 SARS-CoV-2 viral kinetics severe acute respiratory syndrome Coronavirus Significance Strategy survival symptom onset translate Treatment Treatment strategies Viral viral clearance viral dynamics viral kinetics Viral load Virological virus virus pathogenesis younger patient younger patients [DOI] 10.1073/pnas.2017962118 PMC 바로가기 [Article Type] 422
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene ExpressionReview Published on 2021-02-022022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] activity acute respiratory syndrome Amino acid antiviral responses biological function cell interaction cellular cleavage contribute Control Coronaviruses CoVs disrupt endonucleolytic cleavage evade function Gene Expression genomes highly pathogenic Host host gene expression host gene expression suppression host mRNA human coronavirus identity involved mechanism MERS-CoV Middle East mRNA mRNA degradation nonstructural protein 1 nsp1 pathogenic SARS-CoV SARS-CoV-2 suppresse syndrome translation translational suppression viral mRNA viral pathogenicity Viral protein viral replication virulence virulence factor virus virus pathogenesis [DOI] 10.3390/cells10020300 PMC 바로가기 [Article Type] Review