Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approachResearch Published on 2024-03-062024-09-05 Journal: Conflict and Health [Category] update2024, [키워드] Community based surveillance community health epidemic diseases epidemic preparedness Health risks Outbreaks public health volunteers [DOI] 10.1186/s13031-024-00578-5 PMC 바로가기 [Article Type] Research
Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivitySARS-CoV-2 변이체 B.1.617 분석: 숙주 친화성, 단백질 분해 활성화, 세포-세포 융합 및 중화 민감도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity Adenovirus adenovirus vaccine Amino acid B.1.617 caused cell-cell fusion cell–cell fusion cells Characteristics Convalescent patients COVID-19 pandemic D614G variant Delta escaped furin host tropism human cells immunized inactivated Inactivated vaccine India Infection Infectivity L452R mAbs Mutation mutations neutralization neutralization activities neutralization activity pathogenicity proteolytic activation pseudotyped Pseudotyped virus Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera T478K Transmissibility transmitted variant variants viruses volunteers [DOI] 10.1080/22221751.2022.2054369 PMC 바로가기 [Article Type] Article
New insights into antibody levels against SARS-CoV-2 for healthcare personnel vaccinated with tozinameran (Comirnaty)Article Published on 2022-11-032022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] activated addition addressed administration Alto Andújar antibody booster dose COVID-19 determine Dilution Elecsy Evolution exhibited Germany Guadalquivir healthcare personnel Healthcare professional humoral IgG in vitro infected patients material Neutralizing antibodies New non-infected pandemic platform Roche SARS-CoV-2 SARS-CoV-2 vaccine second dose serum sample Spike protein subject Thermo Fisher Scientific titer total antibody vaccination Vaccine Volunteer volunteers [DOI] 10.1371/journal.pone.0276968 PMC 바로가기
The impact of COVID-19 on implementation of mass testing, treatment and tracking of malaria in rural communities in Ghana: A qualitative study가나 농촌 지역사회에서 말라리아 대량 검사, 치료 및 추적 실시에 대한 코로나19의 영향: 질적 연구Article Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] 말라리아, 진단, [키워드] addition affected analysed Analysis children Community Complication conducted Coverage COVID-19 COVID-19 pandemic Effect eight English finding group Health health worker identify implementation increase in Intervention introduced malaria mass methodology observation pandemic parent participant public health respond responsible Transcription translated treat Treatment Volunteer volunteers was used were recorded [DOI] 10.1371/journal.pone.0275976 PMC 바로가기
An electrochemical aptasensor with N protein binding aptamer-complementary oligonucleotide as probe for ultra-sensitive detection of COVID-19N 단백질 결합 앱타머-상보성 올리고뉴클레오티드를 COVID-19의 초고감도 검출을 위한 프로브로 사용하는 전기화학적 앱타센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, 치료제, [키워드] affected applied aptamer binding blood sample Blood samples changes in complementary Complementary DNA Concentration conformational COVID-19 COVID-19 epidemic COVID-19 in patients DNA double-stranded Early detection effective Electrochemical aptasensor gold hybridization Incubation linear relationship log logarithm N protein N protein detection probe R 2 Rapid Rapid COVID-19 diagnosis Regenerable aptamer sensor. reported sensor solution target the N protein throat swab throat swabs vaccination volunteers was measured [DOI] 10.1016/j.bios.2022.114436 PMC 바로가기 [Article Type] Article
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityResearch article Published on 2022-10-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined [DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article
Repeat subcutaneous administration of casirivimab and imdevimab in adults is well-tolerated and prevents the occurrence of COVID-19Randomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] administration adverse event antibody Casirivimab clinically conducted COVID-19 death defined demonstrated development dose doses double-blind Efficacy end point evaluate evaluated exploratory hypersensitivity reaction Imdevimab incidence of COVID-19 laboratory-confirmed monoclonal antibody occurred Occurrence occurrence of COVID-19 Odds ratio participant Placebo placebo-controlled trial Prevent proportion Randomized reaction reduction in Repeat reported risk reduction SARS-CoV-2 Seroconversion substantial risk Tolerability treatment period treatment-emergent adverse event uninfected volunteers [DOI] 10.1016/j.ijid.2022.06.045 PMC 바로가기 [Article Type] Randomized Controlled Trial
Optimization of peripheral blood volume for in silico reconstitution of the human B-cell receptor repertoireArticle Published on 2022-09-012022-11-15 Journal: FEBS Open Bio [Category] SARS, 진단, 치료기술, [키워드] Analysis anatomical antibodies antibody Antigen Autoimmune disease B cell B cell receptor repertoire B-cell BCR BCR-based diagnostics calculated change clinically correlation Diagnosis diagnostic Frequency functional FUS HIV human B-cell in silico Next-generation sequencing no increase observation optimization pathology Peripheral blood prognostic receptor recognize reduced SARS-CoV2 sequence significantly higher slight increase statistically significant Support unique Volume volunteers [DOI] 10.1002/2211-5463.13467 PMC 바로가기
Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health: An Observational, Multi-cohort StudyObservational Study Published on 2022-09-012022-10-04 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 임상, [키워드] 95% confidence interval ACE acute infection Admission Affect age aging Analysis association basal BMI body mass index characteristic Community-based cohort contribute COVID COVID-19 COVID-19 infection Effect examined Factor Fever Genetic Health healthy heritability hospital identify Immunesenescence Immunity Including increasing age individual Infection less Linear regression London multivariable multivariable logistic regression observation Older participant Participants positive RT-PCR ROC RT-PCR SARS-CoV-2 SARS-COV-2 infection saturated Sensitivity and specificity Sex temperature temperature regulation Thermoregulation threshold TwinsUK variable volunteers was used [DOI] 10.1093/gerona/glab295 PMC 바로가기 [Article Type] Observational Study
Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in ChileArticle Published on 2022-08-242022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] activate acute respiratory syndrome Adverse reaction age analyzed binding domain blood sample cellular characterized Chilean circulating clinical trial CoronaVac coronavirus coronavirus 2 coronavirus disease COVID-19 dose effective vaccine enrolled healthy humoral IFN-γ IgG immunogenicity Immunoglobulin inactivated incidence induce injection interferon-γ Local measure Mild neutralizing antibody neutralizing capacity Pain peptide Phase 3 phase 3 clinical trial Placebo pool profiles promote Randomly RBD Registered reported respiratory Safe Safety SARS-CoV-2 SARS-CoV-2 antigens second dose secretion separated severe adverse event significant increase subset T cells T-cell Response the vaccine Vaccine Vaccines Volunteer volunteers was performed [DOI] 10.1093/cid/ciab823 PMC 바로가기