vWF – Communicable Diseases Research

Extended coagulation profile of children with Long Covid: a prospective study

Article

Published on 2022-11-012022-11-16
Journal: Scientific Reports [Category] SARS, 치료기술,

Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysis

Review article

Published on 2022-10-012022-10-05
Journal: Thrombosis research [Category] 바이오마커, 진단,

[키워드] ADAMTS13 addition Admission Analysis analyzed Antigen cause cleaving Clinical outcome Coagulation Coagulopathy Cochrane Library cofactor coronavirus disease COVID-19 COVID-19 patient Critical database death deficiency defined Effect endothelial injury estimate fixed FVIII ICU immunothrombosis increase indicated intensive care involved Ligand Meta-analysis metalloproteinase Mortality motif no significant difference non-ICU non-survivor outcome outcomes Patient patients with COVID-19 performed plasma poor prognosis Prognosis protease Quantitative random Result risk SARS-CoV-2 searched severe disease course subgroup analysis survivor Survivors systematic review the Newcastle-Ottawa Scale variable von Willebrand factor vWF Web of Science
[DOI] 10.1016/j.thromres.2022.08.017 [Article Type] Review article

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Article

Published on 2022-09-212022-11-15
Journal: Cardiovascular Diabetology [Category] 바이오마커, 유전자 메커니즘, 진단,

[키워드] absence addition analysed antibodies Anxiety Biomarker C-reactive protein cardiovascular disease Chronic fatigue circulation Clinicians Cognitive impairment Cohort Comorbidities Confusion contribute controls COVID COVID patient COVID-19 Depression detect disease Dyspnoea Evidence explain Failed fibrinolysis fatigue fibrinogen fibrinolytic system granular Health healthy controls Host immune response IL-6 implication increased risk individual Inflammatory inflammatory markers insoluble Kallikrein Long Long COVID mechanism Microclots PASC pathology Patient PF4 plasma Platelet platelet factor 4 platelet hyperactivation presence of antibody prevalent Prevent pro-inflammatory molecule Protein provided questionnaire reduced reported serum CRP sick Symptom thrombosis type 2 diabetes von Willebrand factor vWF
[DOI] 10.1186/s12933-022-01623-4 PMC 바로가기

Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19

내피 세포 활성화의 마커는 COVID-19에서 폐 질환의 중증도와 관련이 있습니다

Article

Published on 2022-05-192022-09-11
Journal: PLoS ONE [Category] 바이오마커,

[키워드] activate activated Activation acute respiratory distress acute respiratory distress syndrome Antigen association Biomarker Biomarkers biomarkers of inflammation characterized chemokines coronavirus coronavirus disease Coronavirus disease-19 Coronavirus infection correlated COVID-19 cytokine Cytokines D-dimer death endothelial Endothelial cell endothelial cells endothelial injury Factor Hypothesis individual Inflammatory response inflammatory state low-flow oxygen Lung disease mechanical ventilation nasal nasal cannula obstruction oxygen Oxygen requirement Oxygenation participant patients with COVID-19 plasma Plasma levels pro-inflammatory cytokine pro-thrombotic Proinflammatory cytokine proinflammatory cytokines Protein Proteins pulmonary disease released respiratory distress Respiratory distress syndrome selectin severe coronavirus disease severe COVID-19 severity single center Support syndrome tested thrombosis vascular disease vascular inflammation vWF with COVID-19 worsening
[DOI] 10.1371/journal.pone.0268296 PMC 바로가기 [Article Type] Article

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

COVID-19 중증도에 대한 유전적 위험은 면역 반응의 결함과 관련이 있습니다

Article

Published on 2022-05-122022-09-11
Journal: Frontiers in Immunology [Category] 변종,

[키워드] ABO association Blood Group cohorts COVID-19 COVID-19 patient cytokine dataset disease disease severity Endothelial dysfunction European functional Functional genomics genetic loci genetic risk genetic susceptibility Genetic variant Genome genome-wide association Genome-wide association studies Genome-wide association study Genomics genotyping GWASs Host Human immune responses immunological independent individual innate immune response pathway Pathways physiological protein level protein levels recent response severe COVID-19 severe disease significantly single-cell susceptibility therapy transcript von Willebrand factor vWF
[DOI] 10.3389/fimmu.2022.859387 PMC 바로가기 [Article Type] Article

The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19

Article

Published on 2022-01-212022-10-28
Journal: Viruses [Category] COVID-19,

The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients

Medicine

Published on 2022-01-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Distinctive Biomarker Features in the Endotheliopathy of COVID-19 and Septic Syndromes

COVID-19 및 패혈성 증후군의 내피병증에서의 독특한 바이오마커 특징

Comparative Study

Published on 2022-01-012022-09-11
Journal: Shock (Augusta, Ga.) [Category] 바이오마커,

[키워드] Activation ADAMTS adhesion analyzed Biomarker Biomarkers both groups circulating clinical disease collected complement Complement activation contributing to Control COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 group COVID-19 patient COVID-19 patients COVID-19 phenotype COVID-19 pneumonia Critical critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients Culture disease disease severity dsDNA dysregulation e parameters endothelial Endothelial cell endothelial cells endothelial damage endotheliopathy except for Factor fibrinolysis fibrinolytic healthy donor healthy donors help heparan sulfate Hospitalization ICU in both groups increased expression information intensive care life-threatening mitigate moderate morbidity and mortality motif NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps parameter pathophysiology Patient Phenotypes plasma samples Pneumonia progression receptor Result Sepsis sepsis syndrome septic Septic shock severity of COVID-19 significantly significantly higher significantly lower SIRS Stage Stress sulfate syndrome systemic inflammatory response systemic inflammatory response syndrome therapeutic strategy thrombomodulin TNF volunteers von Willebrand factor vWF was related with COVID-19
[DOI] 10.1097/SHK.0000000000001823 PMC 바로가기 [Article Type] Comparative Study

Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19

COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응

Immunology

Published on 2021-12-132022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

[키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread
[DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology

Cirrhosis-Associated RAS-Inflammation-Coagulation Axis Anomalies: Parallels to Severe COVID-19

Article

Published on 2021-12-012022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

[키워드] abnormal coagulation abnormality ACE acute respiratory distress acute respiratory distress syndrome Angiotensin-converting enzyme Antigen axis C-reactive protein characterized cirrhosis coagulation parameter correlated COVID patient COVID-19 COVID-19 patients CRP D-dimer Endothelial dysfunction exhibited fibrinolysis healthy subject IL-6 Increased increased risk Inflammation interleukin-6 investigated Liver disease Mild nine parameter Patient patients patients with COVID-19 portal hypertension RAS RAS activity renin-angiotensin-system severe COVID-19 severity significantly syndrome systemic inflammation upregulation venous vWF
[DOI] 10.3390/jpm11121264 PMC 바로가기 [Article Type] Article