Diagnostic performance of molecular and serological tests of SARS-CoV-2 on well-characterised specimens from COVID-19 individuals: The EDCTP “PERFECT-study” protocol (RIA2020EF-3000)Article Published on 2022-09-212022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] affecting Amplicon assays Biorepository Care Clinical diagnosis Clinicians collected conducted confirmed case contribute COVID-19 COVID-19 infection creating diagnosing Diagnosis effective effort ELISA ENhance Epidemiology evaluated Evidence facilitate Fatality rate Follow-up Genetic identify IMPROVE individual individuals management measure molecular Molecular assay molecular assays PCR performed platform point-of-care positive protocol real-time qPCR risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV2 sera Serological assay serological test Serological testing specificity specimen strain Swab transfer translate Treatment well [DOI] 10.1371/journal.pone.0273818 PMC 바로가기
Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiencyArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activity Adverse reaction analyzed Anti-SARS-CoV-2 S antibody Antibody Response Autoimmune Autoimmune diseases B-lymphocytes Cell Cohort cohort of patient comparable Course COVID-19 COVID-19 vaccination CVID deficiency detect Disease activity dysfunction effective Efficacy and safety Elecsy flow cytometry healthy control humoral humoral immune response Hypogammaglobulinemia IFN-gamma immune system Immunity immunization immunoassay immunodeficiency immunoglobulin replacement therapy in healthy individuals increased risk individual Interferon-gamma lymphocyte neutralization Patient Phenotyping pneumococcal provide reactogenicity receptor Safe SARS-COV-2 infection selective Seven subjects Support syndrome T cell response T-lymphocites the disease triggering underlying disease vaccination vaccine response Vero E6 Virus neutralization was performed well X-linked agammaglobulinemia XLA [DOI] 10.3389/fimmu.2022.974987 PMC 바로가기
A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] 1:1 28-day mortality addition Admission Admissions Analysis Appendix 1 benefit Care changes in chronic chronic condition chronic disease chronic liver disease cirrhosis clinical Clinical improvement Clinicians Cohort conducted COVID-19 COVID-19 pandemic criteria disease evaluated exploratory subgroup analysis feasibility generalisability generate global healthcare Health Health Service health team healthcare Healthcare systems heart failure hospitalisation implementation implication include Interdisciplinary health team. interim analysis Intervention intervention arm liver Liver disease Melbourne, Australia Mortality mortality risk New outcome participant Patient performed Prevalence Primary outcome Quality of life randomisation randomised randomised controlled trial RCT readmission recruit recruited recruitment reduced reducing Registered Registration registry required resource rising robust Safe secondary severity small sample size social work Study protocol suggested Treatment Trial well WHO [DOI] 10.1186/s13063-022-06679-x PMC 바로가기 [Article Type] Article
Application of human factors at hybrid meetings: facilitating productivity and inclusivity하이브리드 회의에서 인적 요소의 적용: 생산성 및 포괄성 촉진Review Published on 2022-07-012022-09-11 Journal: The British journal of oral & maxillofacial surger [Category] COVID19(2023년), SARS, 변종, [키워드] application benefit communication conferences COVID-19 COVID-19 pandemic facilitated Factor healthcare Human Human Factors hybrid Hybrid meeting normality omicron Omicron variant participant performance platform productivity risk Self-isolation team Travel variant Viral transmission Virtual well widespread [DOI] 10.1016/j.bjoms.2021.12.055 PMC 바로가기 [Article Type] Review
Impact of COVID-19 emergency on the psychological well-being of susceptible individuals Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료법, [키워드] age Anxiety appear applied being COVID-19 COVID-19 crisis COVID-19 emergency defined disease Effect evaluate Factor Health health emergency healthy higher risk Impact index individual Italian mental health outcome pandemic positive psychological Impact Psychological well-being recruited risk SARS-COV-2 infection second wave social interaction susceptible susceptible individual total score university variable was used well [DOI] 10.1038/s41598-022-15357-6 [Article Type] Research
Infant, pediatric and adult well visit trends before and during the COVID-19 pandemic: a retrospective cohort studyCOVID-19 대유행 전과 동안 유아, 소아 및 성인 방문 경향: 후향적 코호트 연구Article Published on 2022-03-112022-09-11 Journal: BMC health services research [Category] SARS, 변종, [키워드] 95% CI adolescents and adult Adults age Care childhood children Cohort COVID-19 COVID-19 pandemic declined decrease delta variant Eligible patients family Family medicine Health Health care Health care system Infant Infants normalized occurred pandemic Patient pediatric pediatrics prevention primary care Regression model remained retrospective cohort study seasonal variation trend Variation well Well visit. were assessed [DOI] 10.1186/s12913-022-07719-7 PMC 바로가기 [Article Type] Article
Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in PolandCovid-19 Pandemic이 항우울제 및 항발성 제약의 사용 및 폴란드의 병가의 영향Article Published on 2022-02-142022-08-31 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] absence analyzed antianxiety antidepressant antidepressants Anxiety caused Clinical practice Consumption COVID-19 COVID-19 pandemic Depression Diagnosis Impact impacted Interrupted Measures medication mental condition mental health pandemic Patient pharmaceutical Pharmaceuticals physician Poland Psychiatric psychiatric patients reaction Research Sery sick leave significantly strain Stress time Treatment well Workplace [DOI] 10.3390/ijerph19042135 PMC 바로가기 [Article Type] Article
Cyclosporine A Inhibits Viral Infection and Release as Well as Cytokine Production in Lung Cells by Three SARS-CoV-2 VariantsCyclosporine A는 3가지 SARS-CoV-2 변이체에 의한 폐 세포의 바이러스 감염 및 방출 및 사이토카인 생성을 억제합니다Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Anti-inflammatory anti-inflammatory drug anti-SARS-CoV-2 vaccines Antibody neutralization Antiviral antiviral activity approach approved B.1.1.7 benefit Betacoronavirus Betacoronavirus genus Calu3 CaLu3 cells Cell cellular mechanism cellular mechanisms coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients CsA cyclophilin cyclophilin A cyclosporine cyclosporine A cytokine cytokine release Cytokine storm Cytokines dampen death in COVID-19 decrease diffusion disease severity drug Effect Effectiveness exposure to expression Hyperactivation IL-6 IL-8 immune system infected cells Infection interleukin involved knock lung cell lung cells organ P.1 pandemic Patient patients Production progeny virion progeny virions Protein protocol rationale reduce reduce mortality Release released repositioning repurposing respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 patients severe symptom severe symptoms tested therapeutic These data TNF-α transmissible variants treat Treatment variants Viral viral infection Viral RNA viral strain viral strains well [DOI] 10.1128/spectrum.01504-21 PMC 바로가기 [Article Type] Research Article
From Syndemic Lesson after COVID-19 Pandemic to a “Systemic Clinical Risk Management” Proposal in the Perspective of the Ethics of Job Well DoneCommunication Published on 2021-12-212022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] aligned Bayesian approach Bayesian network big data clinical clinical risk management COVID-19 effective element enabling technologies Ethics event Health Service Health services IMPROVE Interpretation Intervention job learning lesson medical ethics observé occurred patient safety Quality quality of care Safety support for policy making sustainability syndemic systemic theory well WHO World Health Organization [DOI] 10.3390/ijerph19010015 PMC 바로가기 [Article Type] Communication
Pulmonary embolism and COVID-19: A comparative analysis of different diagnostic models performanceResearch article Published on 2021-12-012022-10-05 Journal: The American journal of emergency medicine [Category] 진단, [키워드] Accuracy Algorithm Algorithms Analysis applied approach Comorbidities Computed tomography Computed tomography pulmonary angiography coronavirus COVID-19 COVID-19 patient COVID-19 patients CTPA cut-off D-dimer D-dimer levels decrease Department diagnostic elevated Emergency limit objective Occurrence Patient patients Predictive predictor Probability pulmonary angiography Pulmonary embolism raising reduction Result Retrospective study risk factor SARS-COV-2 infection screening test sensitivity specificity Symptom threshold well [DOI] 10.1016/j.ajem.2021.09.004 [Article Type] Research article