Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemicArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant clinical testing Community complementary COVID-19 COVID-19 disease COVID-19 incidence deaths Delta VOC disease disease incidence Effectiveness expected Hospital admissions ICU admissions immunization incidence Infection Laboratory positive cases Metrics moderate omicron pandemic Population positive SARS-CoV-2 shown Spread Surveillance understanding vaccination vaccination rate Vaccine virulence VoC waned wastewater weakened widespread wildtype WWS. [DOI] 10.1016/j.scitotenv.2022.158458 PMC 바로가기
Impact of SARS-CoV-2 variants on mobility and air pollution in the United KingdomArticle Published on 2022-12-102022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] activity affecting Algorithm Alpha baseline baseline level baseline levels contagiousness COVID-19 COVID-19 case death Delta event Government Immunity Impact Increases measure NO(2) normality Pollution prevalent Public public health reduced remained Result returned SARS-CoV-2 variant significant increase significantly social contact Spread Traffic Traffic. United Kingdom variant variants virus wildtype [DOI] 10.1016/j.scitotenv.2022.158279 PMC 바로가기
Discriminative electrochemical biosensing of wildtype and omicron variant of SARS-CoV-2 nucleocapsid protein with single platformArticle Published on 2022-11-152022-11-15 Journal: Analytical biochemistry [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody Antigen COVID-19 detect Electrochemical biosensing platforms evaluated linear Microscopy nasopharyngeal swab sample nucleocapsid antigen Nucleocapsid antigen protein omicron Omicron variant platform produced Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid the SARS-CoV-2 Voltammetry. wildtype X-ray X-ray spectroscopy [DOI] 10.1016/j.ab.2022.114898 PMC 바로가기
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기
Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screeningArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 변종, 치료제, [키워드] amino acid residue antiviral drug binding binding sites. Cefixime Ceftazidime cell entry Cephalosporin derivative clinical evaluation coronavirus 2 Critical derivative drug Drug screening example hACE2 human Angiotensin-converting enzyme identification Infection inhibited Interaction key amino acid live SARS-CoV-2 molecular docking Mutation peptide Pseudotyped virus pseudovirus RBD Receptor binding domain respiratory Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD Support targets tested the RBD the spike protein variants virus was determined wild type wildtype Wuhan [DOI] 10.1016/j.virusres.2022.198915 PMC 바로가기
Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2Article Published on 2022-10-182022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] antibody antibody production appear BNT162b2 BNT162b2 mRNA vaccine convalescent correlated COVID-19 COVID-19 patients decrease detectable eight elicit functional generate Heterologous humoral humoral immune response Immunity immunization increase induce marker mRNA vaccination mRNA vaccine mucosal mucosal immune NAb Neutralizing neutralizing capacity of BNT162b2 omicron peaked progression proportion protective immune response RBD RBD-binding antibody reduced Saliva SARS-CoV-2 second dose second vaccination sera significantly Spike protein subsequent the RBD the S1 subunit the SARS-CoV-2 vaccinated individual vaccination Vaccine vaccinee vaccinees variant virus neutralizing titers VoC VOCs wildtype [DOI] 10.1371/journal.pone.0263861 PMC 바로가기
PrimedSherlock: a tool for rapid design of highly specific CRISPR-Cas12 crRNAsArticle Published on 2022-10-142022-11-15 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] assays automated benefit bioinformatics Cas12 nuclease assay Cas12a Combination conserved CRISPR CRISPR-Ca CRISPR-Cas12 Critical demonstrated Dengue diagnostic diagnostics Efficiency facilitated FDA approval field Field forward diagnostics flavivirus genomes genomic HIV In-vitro Intensive isothermal isothermal amplification manual curation Nile nucleases nucleic acid offer parameter Pathogens platform polymorphism PrimedRPA PrimedSherlock primer primer pair Primers qRT-PCR regions RNA robust SARS-CoV-2 Serological assay serotype SHERLOCK significantly specificity strain Strains target targets Vector-borne disease West West Nile wildtype Zika Zika. [DOI] 10.1186/s12859-022-04968-5 PMC 바로가기
Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccinesArticle Published on 2022-10-042022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation antibody Antibody Response Antibody titre antigen exposure baseline benefit binding BNT162b2 boost CD4+ T cell CD8+ Cellular immune response clinical trial Course COVID-19 Delta dose ELISA ELISPOT enhanced global public health glycoprotein Heterologous highest humoral immune memory immune response immunological increase in individual majority marker median mRNA mRNA COVID-19 vaccine mRNA vaccination mRNA vaccine naïve natural infection neutralising antibody titre omicron participant Participants PCR proportion question receiving recruited response RNA SARS-CoV-2 vaccine second dose seroconverted significantly higher subject the SARS-CoV-2 titre vaccination Vaccination strategy Vaccine variants were measured wildtype [DOI] 10.1371/journal.ppat.1010885 PMC 바로가기
Identification of serum metabolites enhancing inflammatory responses in COVID-19Article Published on 2022-10-012022-11-15 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype [DOI] 10.1007/s11427-021-2099-7 PMC 바로가기
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variantsArticle Published on 2022-09-262022-11-15 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Affinity maturation analysis Analysis antibody Antibody Response Antigen antigens caused cleavage site Combination coronavirus coronavirus determine Evolution fusion peptide immunization immunogen Infection Mutation outbreak predict promote PROTECT RBD expression SARS-CoV-2 variant sequence spike Strains Structure targets the antibody response Vaccine variant variants virus wildtype zoonotic coronavirus [DOI] 10.1371/journal.pcbi.1010563 PMC 바로가기