Impact of the coronavirus disease 2019 lockdown on Schistosoma host Oncomelania hupensis density in Wuhan코로나바이러스 질병 2019 잠금이 우한의 주혈흡충 숙주 Oncomelania hupensis 밀도에 미치는 영향Article Published on 2022-02-012022-09-11 Journal: Acta tropica [Category] COVID19(2023년), SARS, 치료기술, [키워드] average calculated colony coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 pandemic disease District eliminated event exhibited followed by Frame highest Host Impact Infection infection control lockdown measure Measures Novel coronavirus novel coronavirus disease occur occurrence rate Oncomelania hupensis density outbreak risk Risk scores Schistosoma Schistosomiasis severity SigmaPlot Snail Transmission Village was used worm Wuhan Wuhan, China [DOI] 10.1016/j.actatropica.2021.106224 PMC 바로가기 [Article Type] Article
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus SpeciesReview Published on 2022-01-272022-10-30 Journal: Marine Drugs [Category] Coronavirus, SARS, [키워드] Conus Andaman Islands biomedical compounds Biomedical research candidate categories coast Conotoxin Conus correlation demonstrated distribution map Drug discovery Evolution exhibited explicit feeding habit functional highlight highlighting hotspot include malaria therapy multi Neglected Neogene observation Perspective pharmaceutical Phylogenetic relationship Phylogenetic tree Potential promote receive Reclaiming Research resource SARS-CoV-2 Specy urgency Virological warm worm worms [DOI] 10.3390/md20020105 PMC 바로가기 [Article Type] Review
The Curious Case of Earthworms and COVID-19Perspective Published on 2021-10-142022-10-28 Journal: Biology [Category] COVID-19, [키워드] activate Anti-viral Bacteria can be used Charles Darwin coronavirus 2 COVID-19 COVID-19 vaccines Earthworm elicited example Gene Expression Genome human SARS-CoV-2 immune immune system Immunity in vivo information invertebrate kill lysenin mechanism mechanisms Nanoparticles non-toxic organism potential risk Protein Proteins respiratory SARS-CoV-2 Scientific community shown simple therapeutic Toxicity unique virus viruses worm [DOI] 10.3390/biology10101043 PMC 바로가기 [Article Type] Perspective
Annelid genomes: Enchytraeus crypticus , a soil model for the innate (and primed) immune systemArticle Published on 2021-09-062022-10-29 Journal: Lab Animal [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Annelid Annelida antibiotic Bioscience cell entry Combination coronavirus SARS-CoV-2 distribution elements Environmental sciences enzyme gene families Genes Genome Genomics highlight homolog horizontal gene identify Illumina immune system innate immune system Innate immunity Interaction invertebrate involved nuclear P450 platform Protein reference genome Sequencing Significant Stress transfer worm [DOI] 10.1038/s41684-021-00831-x PMC 바로가기 [Article Type] Article
TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infectionTOR는 철 신호를 박테리아 감염에 대한 숙주의 타고난 방어와 연결하는 분자 스위치로 기능합니다.Research Article Published on 2021-03-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating autophagy Bacterial infection Bacterial infections Caenorhabditis elegan Caenorhabditis elegans conditions defend Defense Degradation essential nutrient ferritin function Host host defense host innate immunity host-pathogen interactions hosts increase in Increased induce Infection iron modulate modulating molecular molecular mechanism organism pathogen pathogenic pathogenic bacterium Pathogens PROTECT Protein protein level Rapamycin regulator required reveal Salmonella subunit suppresse suppressed survival target transcript transcripts transition turn upregulated worm worms [DOI] 10.1371/journal.pgen.1009383 PMC 바로가기 [Article Type] Research Article
Between a hygiene rock and a hygienic hard place Avoiding SARS-CoV-2 while needing environmental exposures for immunityReview Published on 2021-02-122022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] acute respiratory syndrome adverse effect Adverse reaction allergic alleviate Autoimmune disease Avoiding benefit characterized clinicians and researcher Community Complete component coronavirus coronavirus disease country COVID-19 COVID-19 pandemic described disorders Effect Effects environmental exposure evolutionary mismatch Health hygiene immune function immune response Immunity infectious agents Infectious disease intestinal many case measure Neuropsychiatric Pandemics plants predicted Prevent problem provided reduced researcher SARS-CoV-2 social distancing supported Treatment worm [DOI] 10.1093/emph/eoab006 PMC 바로가기 [Article Type] Review
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactionsBioGRID 데이터베이스: 선별된 단백질, 유전 및 화학적 상호작용의 포괄적인 생물의학 자원Tools for Protein Science Published on 2020-11-232022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome addition annotation BioGRID Biological biological network Biomedical research build can be used captures carried Cas9 cause cell lines cellular chemical interaction Community Complex network Complex networks COVID‐19 COVID‐19 CRISPR CRISPR screen CRISPR Screens curated database dataset datasets disease drug target drugs example experimental evidence extension facilitate generate Genetic genetic interaction genetic interactions genetic screens Health Human include Interaction interactions Modification mouse open organism phenotype post‐translational modification Protein protein interaction Regulation resource respiratory SARS‐CoV‐2 virus Screen Severe acute respiratory syndrome single mutant small molecule Small molecules species specific disease ubiquitin‐proteasome system worm yeast [DOI] 10.1002/pro.3978 PMC 바로가기 [Article Type] Tools for Protein Science
Old friends meet a new foe A potential role for immune-priming parasites in mitigating COVID-19 morbidity and mortalityReview Published on 2020-10-202022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] Affect Area biocultural perspectives Care characterized contribute coronavirus 2 COVID-19 COVID-19 disease severity Cytokine storm Cytokines death decrease disease Endemic exacerbate expression Factor Friend host cells humans hygiene hypothesis immune immune response immune system immune-priming immunosuppressive infect Infection infections Inflammation Inflammatory inflammatory immune responses intestinal lack Medicine mismatch paradigm morbidity and mortality Old Friends Hypothesis outcome outcomes overactive parasite pathogen Perspective receptor reduce reducing Regulatory required respiratory risk SARS-CoV-2 SARS-COV-2 infection severe symptom soil-transmitted helminths STH stimulate suppress Symptom the disease tissue damage triggered virus worm worms [DOI] 10.1093/emph/eoaa037 PMC 바로가기 [Article Type] Review
Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans미토콘드리아와 식단 사이의 상호 작용은 Caenorhabditis elegans에서 병원체와 스트레스 저항을 매개합니다Research Article Published on 2019-03-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect alleviation Amino acid amino acid metabolism Anemia arise B12 bacterial pathogen Bacterial pathogenesis Bacterial pathogens biochemical Caenorhabditis canonical clearance cofactor condition Critical Defense deficiency demonstrated diet E . coli elegan elegans excess exhibited exposure to Genetic Health homeostasis Host host defense improvement Improvements Increasing independent independent of Interaction intermediate knockdown Laboratory Loss metabolism methylmalonyl-CoA microbiota mitochondrial mitochondrial dysfunction neurological defects organism overexpression pathogen pathogenic Pathogens Pathways phenotype physiological propionate RNAi-mediated gene sensitivity Stress Support survival susceptibility variety vitamin B12 vitamin B12 deficiency were used worm worms [DOI] 10.1371/journal.pgen.1008011 PMC 바로가기 [Article Type] Research Article
Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogensHeme peroxidase HPX-2는 Caenorhabditis elegans를 병원체로부터 보호합니다Research Article Published on 2019-01-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Author Caenorhabditis elegan Caenorhabditis elegans catalytic cause changes in characterization complexity component conditions contribute Defense demonstrated Disruption DNA domain downstream elegan elegans ENCODE enzyme exhibited expression fluorescent function generate genes encoding greater heme Host host defense host tissue hydrogen hydrogen peroxide hypodermis indicated Infection Infectious disease Infectious diseases information Innate immunity intestinal involved labeling limit mammalian mechanism microbe microbial microbial infection morbidity morbidity and mortality Morphological mutant NADPH NADPH oxidase observation organ oxygen pathogen pathogenic Pathogens pathway peroxidase peroxidases pharynx previous study PROTECT Protective Reactions reactive oxygen species regulated required residue RNA interference RNA-seq analysis RNAi ROS ROS production shown survival therapy tissue worm [DOI] 10.1371/journal.pgen.1007944 PMC 바로가기 [Article Type] Research Article