xViTCOS: Explainable Vision Transformer Based COVID-19 Screening Using RadiographyxViTCOS: 방사선 사진을 사용한 설명 가능한 비전 변환기 기반 COVID-19 스크리닝Article Published on 2022-12-082022-09-10 Journal: IEEE Journal of Translational Engineering in Healt [Category] SARS, 치료기술, [키워드] AI for COVID-19 detection capture Care Chest radiography CNN code collapse country COVID-19 COVID-19 positive patient COVID-19 positive patients CT scan and CXR deep deep learning demonstrated diagnosis of COVID-19 feature globe Health Health care Health care system Healthcare system help identify imperative implementation inherent issue learning Localization outbreak outperform Radiography Radiologists reduce Region researcher resources RT-PCR Screening screening test Spread the disease transfer transformer verge Virus Disease vision vision transformer X-ray [DOI] 10.1109/JTEHM.2021.3134096 PMC 바로가기 [Article Type] Article
A hybrid random forest deep learning classifier empowered edge cloud architecture for COVID-19 and pneumonia detectionResearch article Published on 2022-12-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy Affect Algorithm Classifier cloud computing complex computation conducted COVID-19 COVID19 CT scan dataset datasets deep deep learning detect diagnose effective Efficiency evaluate False positives forest global pandemic Healthcare industry heat Heat Transfer Search algorithm identify immunization inefficient Interaction less lung CT scan methodology offer outcomes overcome Patient Pneumonia predict PROTECT random Random forest resource Support the patient virus Web services X-ray [DOI] 10.1016/j.eswa.2022.118227 [Article Type] Research article
Discriminative electrochemical biosensing of wildtype and omicron variant of SARS-CoV-2 nucleocapsid protein with single platformArticle Published on 2022-11-152022-11-15 Journal: Analytical biochemistry [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody Antigen COVID-19 detect Electrochemical biosensing platforms evaluated linear Microscopy nasopharyngeal swab sample nucleocapsid antigen Nucleocapsid antigen protein omicron Omicron variant platform produced Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid the SARS-CoV-2 Voltammetry. wildtype X-ray X-ray spectroscopy [DOI] 10.1016/j.ab.2022.114898 PMC 바로가기
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variantArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme coronavirus COVID-19 domain Effect ENhance human ACE2 human Angiotensin-converting enzyme humans infect investigated mouse angiotensin-converting enzyme 2 Mutation Mutational hotspots N501Y Omicron variant question raised RBD receptor Receptor-binding domain (RBD). SARS-CoV-2 Spread the RBD viral adaptation X-ray X-ray crystallography [DOI] 10.1073/pnas.2206509119 PMC 바로가기
Classification and Detection of COVID-19 and Other Chest-Related Diseases Using Transfer LearningArticle Published on 2022-10-192022-11-15 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Algorithms articles automatic detection Bacterial Chest X-ray image classification Classifier CNNs Convolutional neural networks COVID-19 database datasets deep learning detect detection diagnostic different diseases disease FIVE help IMPROVE learning nine Other Pneumonia Pneumothorax radiological reverse transcription suspected patient transfer transfer learning Tuberculosis tuberculosis. Viral pneumonia was used X-ray [DOI] 10.3390/s22207977 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point structure-based drug design. unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography [DOI] 10.3390/ijms232012448 PMC 바로가기
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low ToxicityArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-SARS-CoV-2 antiviral activity antiviral agent binding caspase 3 cathepsin Critical cytotoxicity derivative direct-acting drug design exhibit inhibit inhibitor interactions M pro piperazine protease SARS-CoV-2 Spread Structure target therapy for COVID-19 variants X-ray [DOI] 10.1021/acs.jmedchem.2c01146 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors선택적인 SARS-CoV/SARS-CoV-2 파파인 유사 프로테아제 억제제의 설계 및 개발을 위한 특권적인 백본인 Chalcone-amideReview Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus amide antiviral immune responses backbone binding carbon caused chalcone Chalcone amide (N-benzylbenzamide) complex Compound coronavirus COVID-19 COVID-19 pandemic Critical crystal structure effort functional Genetic Host immune responses in some increase Infection inhibitor inhibitors inhibitory potency introduced maturation methyl group Papain Papain-like protease Papain-like protease (PLpro) performed PLPro polyproteins protease Protein Regulation Replication reported Research SAR SARS-CoV SARS-CoV-2 Screening selective shown similarity Structure therapeutic agent therapeutic agents Treatment treatment of COVID-19 understanding unique X-ray X-ray crystal structure. [DOI] 10.1016/j.ejmech.2022.114572 PMC 바로가기 [Article Type] Review
COVID-19 detection on Chest X-ray images: A comparison of CNN architectures and ensemblesResearch article Published on 2022-10-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy applied chest X-ray Chest X-ray images CNN CNNs complementary Convolutional neural network Convolutional neural networks COVID-19 CXR dataset decrease detect diagnostics disease effective Efficacy FIVE global pandemic instance instances Patient RT-PCR screening strategy Spread tested transfer learning X-ray [DOI] 10.1016/j.eswa.2022.117549 [Article Type] Research article