Surveillance of SARS-CoV-2 in nine neighborhood sewersheds in Detroit Tri-County area, United States: Assessing per capita SARS-CoV-2 estimations and COVID-19 incidenceResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome Assessing Biomarker Biomarkers collected Community Comparisons Concentration coronavirus correlation COVID-19 COVID-19 burdens COVID-19 case COVID-19 incidence creatinine cumulative demographic characteristics demographics Detroit Detroit Tri-County area Epidemiology genomic indicate Infection N1 and N2 nine normalized parameter polymerase chain Population predict quantified reduced RNA concentration SARS-CoV-2 SARS-CoV-2 RNA normalization screened selected suggested the disease transcriptase wastewater Wastewater-based epidemiology with COVID-19 xanthine [DOI] 10.1016/j.scitotenv.2022.158350 [Article Type] Research article
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과Article Published on 2022-08-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine [DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article
Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19Review Article Published on 2021-08-052022-10-29 Journal: International Journal of Inflammation [Category] COVID-19, [키워드] activating Anti-inflammation chemokine complex condition convert coronavirus disease COVID-19 CSS Cytokine storm syndrome DAMP Endothelial cell enzyme expressed expression hydroxyl radical hyperinflammation induce Inflammasome Inflammatory response Inflammatory responses inhibitor neutrophil Proinflammatory cytokine purine reduced respiratory respiratory epithelial cells respiratory syncytial virus respiratory viral infection response review superoxide radical therapy uric acid xanthine [DOI] 10.1155/2021/1653392 PMC 바로가기 [Article Type] Review Article
Can pentoxifylline and similar xanthine derivatives find a niche in COVID-19 therapeutic strategies? A ray of hope in the midst of the pandemicResearch article Published on 2020-11-012022-10-05 Journal: European journal of pharmacology [Category] 치료제, [키워드] acute lung injury acute respiratory distress Anti-inflammatory anti-oxidative Antiviral ARDS Asthma blood flow Can clinical feature Clinical outcome clinical study clinical trial Clinical use COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patients Cytokine storm decrease derivative disease drug effective effective drug ENhance Evidence exaggerated immune response excessive inflammation Factor identify immune modulation IMPROVE Infant Inflammation Inflammatory cytokine lack management Methylxanthines multi-organ failure offer Oxygenation pandemic Pentoxifylline Pentoxifylline and caffeine profiles pulmonary diseases pulmonary hypertension required Respiratory function respiratory symptoms severe pneumonia shown specific treatment suppress Symptom syndrome therapeutic tissue TNF-α treat Treatment Tumor xanthine [DOI] 10.1016/j.ejphar.2020.173561 [Article Type] Research article
A Trial of Favipiravir and Hydroxychloroquine combination in Adults Hospitalized with moderate and severe Covid-19: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-10-312022-10-29 Journal: Trials [Category] Coronavirus, MERS, SARS, [키워드] 1:1 accompany adjusted Admission Affair age analyst antibiotic antiviral therapy Arrhythmias blinded Breastfeeding breathing ambient air Care Child-Pugh score Chronic kidney disease city classical clinical clinical effectiveness Clinical improvement clinical sample clinical symptom clinically Coma Combination Comorbidity comparator Compliance conducted control arm control group Controlled clinical trial COVID-19 current Dammam data entry death deficiency defined diagnosed with COVID-19 dialysis discharge discharged disease disease onset dissemination drug ECMO effective sample size Efficacy Efficacy and safety eight element enrolled Enrollment evaluate Evidence experimental arm extracorporeal membrane oxygenation Faisal Favipiravir female G6PD Glucose-6-phosphate hereditary xanthinuria HIV hospital Hospital admission Hospitalized Hydroxychloroquine Hyperuricemia ICU admission Imam immunosuppressive in vitro include information Intervention intravenous fluid invasive ventilation investigator Jeddah King less limit Liver damage Major malignancy medication moderate multicenter Multicenter trial Myocardial infarction noninvasive nonpregnant number objective ongoing trial outcome oxygen saturation Palliative care participant Patient PCR pregnant primary endpoint prior diagnosis prognostic prolonged QT interval protocol QT interval randomised randomised controlled trial randomization Randomized receiving recruitment reference risk Sample size SARS-CoV-2 Saudi Arabia selected seven-category ordinal scale Standard Stratification study drug Study protocol subject supplemental oxygen Supportive treatment Symptom System tablets the patient therapeutic agent therapy transferred Treatment Trial ULN Urinary tract use of hydroxychloroquine vasopressor support ventricular viral infection Web website with COVID-19 xanthine [DOI] 10.1186/s13063-020-04825-x PMC 바로가기 [Article Type] Letter
Synthesis of N , N ′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: “Suggested potent anti-inflammatory agent against COVID-19”Articles Published on 2020-08-252022-10-31 Journal: Human & Experimental Toxicology [Category] Coronavirus, [키워드] activity addition Alpha alteration animal model Anti-inflammatory anti-inflammatory agent antioxidant enzymes ATP biological activity Blood blood corpuscle Bone marrow C-reactive protein cartilage chloride complex COVID-19 cytochrome c oxidase declining effective elevated Factors Gene Expression GSH histological IL-6 IMPROVE Infection Inflammation male marker membrane mitochondrial Mitochondrial function mitochondrial potential myeloperoxidase Necrosis Osteoarthritis parameters pathophysiological Randomly reactive oxygen species screened serum Severe infection significant effect Symptom synthesis three group TNF-a Transmission treated with COVID-19 xanthine [DOI] 10.1177/0960327120945779 PMC 바로가기 [Article Type] Articles