Reduced humoral response to a third dose (booster) of SARS-CoV-2 mRNA vaccines by concomitant methotrexate therapy in elderly patients with rheumatoid arthritisArticle Published on 2022-10-012022-11-15 Journal: RMD Open [Category] COVID19(2023년), SARS, 진단, [키워드] Affect binding antibody unit BNT162b2 booster booster vaccination Concomitant concomitant treatment COVID-19 disease dose Efficacy Elderly patient had no Health authority humoral humoral immune response IgG increase IQR Kruskal-Wallis test median methotrexate monotherapy mRNA vaccine mRNA vaccines mRNA-1273 Musculoskeletal Patient patients PROTECT RBD receiving Receptor binding domain reduce reduced Rheumatoid rheumatoid arthritis risk SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccination second dose severe COVID-19 shown significantly the SARS-CoV-2 therapy treated vaccination was measured younger patient [DOI] 10.1136/rmdopen-2022-002632 PMC 바로가기
Quantitative analysis of RT-PCR test results for SARS-CoV-2 diagnostics across Poland during COVID-19 pandemic: Comparison between early stage and major pandemic waves in 2020 and 2021 with reference to SARS-CoV-2 variantsArticle Published on 2022-09-012022-11-15 Journal: Advances in medical sciences [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% confidence interval affected age amplification Analysis analysis of variance analyzed Bonferroni correction COVID-19 COVID-19 case cycle threshold diagnostic diagnostics difference displaying early stage Epidemiology exhibited First wave greater groups inaccuracy limit of detection molecular testing nucleic acid amplification test pandemic Patient patients Poland polymerase chain positive result positive test result ranged recorded reverse transcription risk RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 positive RT-PCR SARS-CoV-2 variant SARS-CoV-2 virus single center tested variant virus were used younger patient [DOI] 10.1016/j.advms.2022.09.002 PMC 바로가기
Ad-hoc preoperative management and respiratory events in pediatric anesthesia during the first COVID-19 lockdown-an observational cohort studyObservational Study Published on 2022-08-182022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] ad-hoc airway airway manipulation Analysis Anesthesiology children clinical contribute COVID-19 Elective surgery Endotracheal intubation event events general anesthesia intraoperative lockdown management National no significant difference Observational cohort study parameter Patient pediatric peripheral oxygen saturation Primary outcome Registered Regression Risk factors significant difference Society SpO2 status unique younger patient [DOI] 10.1371/journal.pone.0273353 PMC 바로가기 [Article Type] Observational Study
Vaccination against SARS-CoV-2 in Haemodialysis Patients: Spike’s Ab Response and the Influence of BMI and Age혈액 투석 환자의 SARS-CoV-2 예방 접종: Spike의 Ab 반응과 BMI 및 연령의 영향Multicenter Study Published on 2022-08-152022-09-12 Journal: International Journal of Environmental Research an [Category] SARS, 진단, [키워드] age antibody BMI BNT162b2 mRNA body mass index carried Chronic kidney disease Cohort cohort of patient Complete composed control group correlation COVID-19 declined dialysis Elderly patient faster greater groups humoral Humoral response identify IgG IgG antibody immune response immune system Immunity influence median multicenter older patient participant Patient Pfizer-BioNTech Portugal response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection selected serum significantly spike the median titres vaccination Vaccine younger patient [DOI] 10.3390/ijerph191610091 PMC 바로가기 [Article Type] Multicenter Study
Acute infectious supraglottitis in adult population: epidemiology, management, outcomes and predictors of airway interventionObservational Study Published on 2022-08-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] airway airway management association Characteristics cohort of patient COVID-19 pandemic diagnosed distress duration of symptom eight Epidemiology Epiglottic abscess epiglottitis Factor Hospital admission Hypersalivation identify incidence incidence rate increase in independent Intervention Intubated Logistic regression analysis management men outcome Patient predictor presenting required retrospective risk factor Risk factors severity single-center smoking stratified Supraglottitis Supraglottitis. the median the patient to define Treatment was performed women younger patient [DOI] 10.1007/s00405-022-07365-z PMC 바로가기 [Article Type] Observational Study
Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome급성 COVID-19 및 장기 COVID-19 증후군과 관련된 사이토카인 프로필Article Published on 2022-06-302022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute COVID-19 advanced age age clinical conditions clinical presentation Clinical presentations clinical status Cohort Comorbidities Comorbidity COVID COVID-19 COVID-19 treatment cytokine cytokine level cytokine levels cytokine profile Cytokines diagnosed with COVID-19 elevated evaluated Factor group IL-10 IL-17 IL-2 IL-4 IL-6 IL-6 level Long Long COVID-19 marker Mild mild cases moderate no significant difference Patient patients prevention strategies profile risk factor sample collection SARS-CoV-2 serum Serum level severe COVID-19 severity of COVID-19 subject syndrome target TNF-α Treatment younger patient younger patients [DOI] 10.3389/fcimb.2022.922422 PMC 바로가기 [Article Type] Article
Contrasting Epidemiology and Population Genetics of COVID-19 Infections Defined by Multilocus Genotypes in SARS-CoV-2 Genomes Sampled Globally전 세계적으로 샘플링된 SARS-CoV-2 게놈의 다중 유전자형에 의해 정의된 COVID-19 감염의 대조 역학 및 인구 유전학Article Published on 2022-06-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] aligned allele frequency alleles Alpha Amino acid amino acids Analysis Asia association Beta caused Cluster Clustering codon component continent continuous surveillance COVID-19 COVID-19 case COVID-19 incidence COVID-19 vaccine COVID-19 vaccines criteria deaths delta variant demographic data demographics demonstrated dependent on discriminant analysis distribution eight epidemiological Epidemiology Evolution Gamma Genetic genetics Genome genomes Genomic surveillance Genotype genotyping geographical regions GISAID help higher risk Inclusion inclusion criteria Intervention linkage Local loci majority matrix MONITOR multilocus Mutation mutation and transmission. North North America nucleocapsid older patient older patients ORF1ab ORF3a ORF8 persistence polymorphism Population populations predominant Prevalence reference genome repertoire Result risk of infection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 reference genome selected South America spatiotemporal Spread suggested the SARS-CoV-2 These data Transmission utility variant variants variants of concern Viral transmission VoC VOCs younger patient younger patients [DOI] 10.3390/v14071434 PMC 바로가기 [Article Type] Article
Changes in self-harm- and violence-related urgent psychiatric consultation in the emergency department during the different stages of the COVID-19 pandemicObservational Study Published on 2022-06-072022-10-05 Journal: BMC Psychiatry [Category] 임상, [키워드] affected age baseline change changed changes in coronavirus disease COVID-19 COVID-19 pandemic declined defined demographic data emergency department evaluated less men mental health no significant difference pandemic Patient physical proportion Psychiatric psychiatric consultation raise retrospective seeking self-harm Sex significantly Stage Taiwan the median the patient treated Violence were recorded younger patient [DOI] 10.1186/s12888-022-04029-4 PMC 바로가기 [Article Type] Observational Study
Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea2019년 델타파 중 50세 이하 환자 중대 코로나바이러스 감염증의 임상적 특성 및 사망률 위험인자: 국내 50세 이상 환자와의 비교Article Published on 2022-06-062022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Adult patients age analyses Analysis analyzed Blood stream infection BMI body mass body mass index Case fatality rate clinical Clinical characteristics clinical feature Clinical features condition conditions coronavirus disease Coronavirus disease 2019 COVID-19 creatinine Critical critical condition death Delta delta variant diabetes Diabetes Mellitus died dominant eight electronic medical record enrolled evaluate Factor Fatality rate General population globe highest highlight hospital Hospitalized hypertension identify independent predictor independent predictors Infection measure mechanical ventilation Mortality mortality risk factor mortality risk factors Multivariate analysis nasal nasal cannula Numerous obese obesity Odds ratio Older older patient older patients oxygen Oxygen therapy Patient PCR-confirmed COVID-19 Prevent progression respiratory Respiratory Support risk risk factor Risk factors Secondary infection severity statistically study period study population the patient therapy total patients underlying disease vaccination vaccination rate Vaccinations variant while women Year Young younger patient younger patients [DOI] 10.3346/jkms.2022.37.e175 PMC 바로가기 [Article Type] Article
Methotrexate significantly reduces the humoral vaccination response against SARS-CoV-2 in older but not younger patients with rheumatoid arthritis메토트렉세이트는 류마티스 관절염이 있는 젊은 환자가 아닌 나이가 많은 환자에서 SARS-CoV-2에 대한 체액성 백신 반응을 유의하게 감소시킵니다Article Published on 2022-06-012022-09-12 Journal: Rheumatology International [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Antigen Arthritis AstraZeneca Combination COVID-19 cross-sectional effect size Elderly patient humoral humoral immune response immune response less medication methotrexate Moderna MTX neutralising antibody not significantly different Older Patient patient subgroup reduce reduced response to vaccination Rheumatoid rheumatoid arthritis SARS-CoV-2 second vaccination significantly study participant Support titre treated vaccinated individual vaccination was reduced younger patient [DOI] 10.1007/s00296-022-05123-2 PMC 바로가기 [Article Type] Article