Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19Article Published on 2022-12-012022-11-16 Journal: Biological trace element research [Category] COVID19(2023년), SARS, 치료기술, [키워드] antioxidant aquaporin both groups chronic disease control group copper correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients determine disease severity elements Endotracheal intubation had no healthy hepcidin Ill in viral indicated individual Infection Inpatient intensive care Invasive mechanical ventilation Level negative PCR test oxidative stress parameter patients with COVID-19 relationship Result SARS-CoV-2 separated sera Significant statistically significant TAC the healthy the patient Total Total antioxidant status Total oxidant status trace Trace element Trace elements. two groups with COVID-19 Zinc [DOI] 10.1007/s12011-022-03400-6 PMC 바로가기
Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione zinc. [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?Review article Published on 2022-10-012022-10-05 Journal: Environmental toxicology and pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Can Concentration Control copper correlated COVID-19 COVID-19 patients death rate deficiency dispersal exhibit facilitate host immune responses increase in independent risk factor Infection Inflammatory cytokine iron modify outcome oxidative stress Patient Prognosis prognostic regulate replication of SARS-CoV-2 risk of infections SARS-CoV-2 Selenium serum serum Cu levels severe COVID-19 significantly higher Spike protein suppress the SARS-CoV-2 viral genome viral replication while worse prognosis Zinc [DOI] 10.1016/j.etap.2022.103937 [Article Type] Review article
Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 비공유 억제제로서의 2-티오벤즈이미다졸의 발견Article Published on 2022-09-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antiviral agent Antiviral agents catalytic site conserved coronavirus antivirals COVID-19 pandemic docking effort in silico inhibitor inhibitors of SARS-CoV-2 inhibitory activity M pro Outbreaks predict predicted protease proteolytic protocol representing SARS-CoV-2 strain structures subset survival synthesis unique Virtual screening Zinc [DOI] 10.1016/j.bmcl.2022.128867 PMC 바로가기 [Article Type] Article
COVID-19 prophylaxis with doxycycline and zinc in health care workers: a prospective, randomized, double-blind clinical trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] Asthma Care chronic obstructive clinical trial Combination combination treatment conducted control groups COVID-19 COVID-19 infection Cycle threshold value decrease demonstrated determine diabete dose double-blind doxycycline Effectiveness Efficacy Health Health care worker hypertension indicated Infection Participants patients with SARS-CoV-2 Placebo polymerase chain prevention of COVID-19 Prophylactic Prophylaxis protective effect pulmonary disease Randomized reduced reverse transcription risk SARS-CoV-2 SARS-COV-2 infection significant decrease therapy Treatment Viral load was measured Zinc zinc. [DOI] 10.1016/j.ijid.2022.06.016 PMC 바로가기 [Article Type] Randomized Controlled Trial
Inhibition of SARS-CoV-2 main protease: a repurposing study that targets the dimer interface of the proteinSARS-CoV-2 주요 프로테아제의 억제: 단백질의 이량체 계면을 표적으로 하는 용도 변경 연구Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] binding energy catalytic dyad catalytically change characterized conformational coronavirus disease coronavirus disease-2019 COVID-19 crystal structure crystal structures Diosmin displaying Drug repurposing DrugBank database elicited eluxadoline Glu166 homodimer inhibition inhibitor inhibitors lethality rate Local M pro main protease modulated molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations novel target site. pandemic performed positive prominence Prophylaxis protease Protein reported residue SARS-CoV-2 Ser1 Simulation Spread target Therapeutics Trajectories trajectory Treatment Virtual screening Wuhan Wuhan, China Zinc [DOI] 10.1080/07391102.2021.1910571 PMC 바로가기 [Article Type] Article
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins vitamins. Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
COVID-19-associated Mucormycosis: A clinico-epidemiological studyObservational Study Published on 2022-09-012022-10-05 Journal: Journal of diabetes and its complications [Category] SARS, 임상, [키워드] Admission age alkaline phosphatase Antibiotics Antifungal treatment Blood Group Chronic kidney disease COVID-19 COVID-19 illness death diabetes diagnosed disease eight enrolled epidemiological expected Follow-up Frequency hyperglycemia increase in India Ivermectin Mortality much lower Mucormycosis occurred Oxygen therapy pandemic Patient patients died Pneumonia Posaconazole positive raised required risk factor RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR serology serum creatinine significantly steroid Steroids survived the patient Treatment uncontrolled use of antibiotics ventilator was done Zinc zinc supplementation zinc. [DOI] 10.1016/j.jdiacomp.2022.108284 PMC 바로가기 [Article Type] Observational Study
Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
Exploring the Impact of ACE Inhibition in Immunity and Disease면역 및 질병에 대한 ACE 억제의 영향 탐색Review Published on 2022-08-042022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] SARS, 치료기술, [키워드] ACE ACE inhibitor ACE inhibitors aldosterone Alter angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme Antibiotic resistance Antigen presentation ARBs Arthritis Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases benefit Cancer Complication contribute coronavirus Diseases elevated enzyme highlight human neutrophil human neutrophils Immune cell immune cell populations immune cells immune regulation Immunocompromise Impact implicated independent independent of Infection Inflammation inflammatory immune cell inflammatory immune cells inhibition inhibitor Lupus Macrophage macrophages malignancy neurodegenerative Neutrophils no effect outcome overactive overexpression pandemic Patient phagocytosis RAAS Renin renin-angiotensin-aldosterone system Research responses rheumatoid arthritis risk ROS SARS-CoV2 therapeutic interventions understanding wake Zinc [DOI] 10.1155/2022/9028969 PMC 바로가기 [Article Type] Review