Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteinsCOVID-19 환자의 마스터 레귤레이터 및 scRNA-seq를 분석하면 ZNF 단백질의 근본적인 anti-SARS-CoV-2 메커니즘이 밝혀집니다Article Published on 2021-09-022022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] abundance activate anti-SARS-CoV-2 antiviral activity COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients demonstrated Express female patient Female patients Gender Gender difference identify Immune cell immune cells Infection male master regulator mechanism Mortality negative correlation outcome Patient positive correlation Prognosis promote Protein Proteins responsible reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq significant difference significantly Stat1 STAT2 suppress survival target gene the SARS-CoV-2 transcription factor transcription factors transcriptional activity Zinc zinc finger protein [DOI] 10.1093/bib/bbab118 PMC 바로가기 [Article Type] Article
The Long-Term Evolutionary History of Gradual Reduction of CpG Dinucleotides in the SARS-CoV-2 LineageCommunication Published on 2021-01-122022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory syndrome adaptation adaptive Amino acid Analysis Antiviral arginine Betacoronavirus bind caused clade coded coronavirus coronavirus disease correlation COVID-19 CpG CpG dinucleotide declining Defense deficiency Degradation dinucleotide dinucleotides evade examined fraction Frequency GC content Genome genomes genus Betacoronavirus Gradual history Host host defense investigated investigation Lineage mechanisms much higher Neutral nucleotide nucleotides occur occurred pandemic predicted proportion Protein recent reduced reduction in sarbecovirus SARS-CoV-2 Scientific community separated simple Specy suggested the Sarbecovirus the SARS-CoV-2 viral genome viral genomes Viral RNA virus Virus evolution zinc finger protein [DOI] 10.3390/biology10010052 PMC 바로가기 [Article Type] Communication
Designed Artificial Transcription Factors Inhibit Hepatitis B Virus Transcription in HepG2.2.15 CellsArticle Published on 2020-01-012023-06-09 Journal: Annals of clinical and laboratory science [Category] B형 간염, [키워드] Artificial transcription factor Core promoter Hepatitis B virus zinc finger protein