Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino ratsArticle Published on 2023-06-242024-09-05 Journal: International journal of biological macromolecules [Category] update2024, [키워드] antiviral activity bovine lactoferrin COVID-19 Nanoparticles pulmonary fibrosis zinc oxide [DOI] 10.1016/j.ijbiomac.2023.125552 PMC 바로가기 [Article Type] Article
In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2SARS-CoV-2의 3CL 프로테아제의 잠재적 억제제로서 Nigella sativa 및 Pimpinella anisum의 종자 추출물을 포함하는 산화아연 기반 나노구조 오일 운반체에 대한 실리코 연구Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applicability candidate carrier characterized clinical trials Compound compounds conformational change coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 docking explained Extract Health histogram imperative inhibitor investigated Ligand ligands MD simulation mixture molecular molecular docking molecular docking studies molecular dynamic simulation molecular dynamics Molecular dynamics simulation MPro nanostructure Nigella Nigella Sativa Oil oleuropein Oxide pandemic Pimpenella anisum Potential protease Protein Research RMSD RMSF SARS-CoV-2 SARS-CoV-2 main protease seed selected stability structural proteins the SARS-CoV-2 trajectory Vaccines variant Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.3390/molecules27134301 PMC 바로가기 [Article Type] Article
On the Efficacy of ZnO Nanostructures against SARS-CoV-2Article Published on 2022-03-112023-06-16 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, [키워드] Antiviral COVID-19 green synthesis nano-antimicrobials Nasopharyngeal swab nucleocapsid protein SARS-CoV-2 zinc oxide [DOI] 10.3390/ijms23063040 PMC 바로가기 [Article Type] Article
Durable nanocomposite face masks with high particulate filtration and rapid inactivation of coronavirusesArticle Published on 2021-12-212022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral approach Chemistry Community Contact coronavirus cosmetic COVID-19 pandemic effective Efficiency Environmental, health and safety issues Face mask filtration greater healthcare IMPROVE inactivation log Mask Materials chemistry Nanoparticles Nanoscale materials Particle Personal protective equipment ranged reduction resulting Safe shown surgical tested unique viral envelope zinc oxide [DOI] 10.1038/s41598-021-03771-1 PMC 바로가기 [Article Type] Article
Iterated Virtual Screening-Assisted Antiviral and Enzyme Inhibition Assays Reveal the Discovery of Novel Promising Anti-SARS-CoV-2 with Dual Activity반복된 가상 스크리닝 보조 항바이러스 및 효소 억제 분석은 이중 활성을 가진 새로운 유망한 Anti-SARS-CoV-2의 발견을 보여줍니다Article Published on 2021-08-222022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] activity Affect analogue Analysis anti-SARS-CoV-2 antiviral activity antivirals drug antivirals drugs association best binding binding affinity binding pocket biological activity calculated clinical trials Combination complex Compound compounds COVID-19 Designer docking dual enzyme Enzyme inhibition Enzymes FIVE furin Health in vitro in vitro antiviral activity indicated inhibition inhibition activity iterated virtual screening lead life M pro MPro Methylene Modification molecular docking molecular dynamics Molecular dynamics simulation novel oxadiazole parent replacing safety profile SARS-CoV-2 significantly Structure suggested therapeutic agent therapeutic agents therapy thermodynamic TMPRSS2 Virtual screening was used Zinc zinc oxide [DOI] 10.3390/ijms22169057 PMC 바로가기 [Article Type] Article
Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2헤스페리딘에 의해 매개되는 항바이러스성 산화아연 나노입자와 항-SARS-CoV-2로서의 항바이러스성 페놀계 물질 간의 in silico 비교 연구Article Published on 2021-07-012022-09-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents assist caused characterized complementary Compound coronavirus COVID-19 curative death docking score evaluated example HAV Hepatitis hepatitis A hepatitis A virus hesperidin highest in silico Infection Isolation leads measure metabolite molecular docking nutraceutical nutraceuticals pandemic pharmaceutical Potential treatment predicted protocol protocols reducing reducing agent required respiratory responsible RNA viruses Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects synthesis TEM tested Treatment virus Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.1016/j.colsurfb.2021.111724 PMC 바로가기 [Article Type] Article
Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea VirusResearch Article Published on 2021-06-232022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus, [키워드] Administered administration affected analyses Analysis anti-inflammatory effect Antiviral average biological process caused Colon Concentration Culture determine diarrhea differentially expressed gene dismutase dose drug Effect epidemic diarrhea Gene ontology growth histologic IL-1 β IL-6 IL-8 implication IMPROVE indicated Infection infectious dose Inflammation inhibit inoculated intestinal intestine lesions mechanism metabolism Microarray morphology neutrophil degranulation oxidative stress Oxide pathway PEDV peroxidase plasma Prevent Protein proteomic randomly divided redox status reduce reduction Replication rescued Result shown significantly increased small intestine TCID three group tissue treat Treatment villus Viral load virus were recorded Zinc zinc oxide [DOI] 10.1155/2021/3055810 PMC 바로가기 [Article Type] Research Article
Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogensarticle Published on 2016-12-312024-09-01 Journal: Colloids and Surfaces B: Biointerfaces [Category] 세균성이질, [키워드] Food pathogens Klebsiella Salmonella Shigella flexneri titanium dioxide zinc oxide [Article Type] article
Feeding a high dosage of zinc oxide affects suppressor of cytokine gene expression in Salmonella Typhimurium infected pigletsarticle Published on 2016-10-312024-09-01 Journal: Veterinary Immunology and Immunopathology [Category] 살모넬라증, [키워드] Piglets Salmonella Typhimurium SOCS zinc oxide [Article Type] article
High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in pigletsResearch Article Published on 2014-03-282022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] added addition Apoptosis cause chloride Concentration control group coronavirus cytokine decrease detectable diarrhea Diseases down-regulation Electrophysiology epithelial evaluate the effect fecal Fecal consistency Final gastroenteritis group groups humoral immune response IFN in vivo incidence Infection interferon intestinal intestinal tract mechanism mitigate Morphometry mucosal immune OAS oral physiological PROTECT protective effect receiving reduce response Result secretion serum antibody response severity shown SLC30A1 SLC30A5 SLC39A4 stimulate TGEV three group transmissible gastroenteritis virus villus virus virus infection was performed Zinc zinc oxide Zinc transporters [DOI] 10.1186/1746-6148-10-75 PMC 바로가기 [Article Type] Research Article