Biochemistry – Communicable Diseases Research

SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection

감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.

Clinical Trial

Published on 2022-01-122022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, 변종, 임상, 치료기술, 치료법,

Analysis of the initial lot of the CDC 2019-Novel Coronavirus (2019-nCoV) real-time RT-PCR diagnostic panel

CDC 2019- 노벨 코로나 바이러스 (2019-NCOV) 실시간 RT-PCR 진단 패널의 초기 로트 분석

Research Article

Published on 2021-12-152022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 치료기술, 치료법, 치료제,

[키워드] 2019-nCoV 3’ end absence addition age amplification Base pairing caused CDC center conducted Contamination Control coronavirus COVID-19 pandemic diagnostic disease control distribution examined False positive False-positive fluorescent Frequency handling identify improvement Improvements increase initial lab Laboratory loci Mutation Novel coronavirus Nucleocapsid gene occurred Panel prevention primer probe probes problem problems public health Quality assurance Quality control reactivity reagent real-time RT-PCR redundancy reported Research resulting reverse primer RT-PCR SARS-CoV-2 detection sensitivity Viral virus detection
[DOI] 10.1371/journal.pone.0260487 PMC 바로가기 [Article Type] Research Article

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

델타의 중화 감소 (B.1.617.2) 예방 접종 후 SARS-COV-2 우려 변형

Research Article

Published on 2021-12-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 변종, 진단,

[키워드] (Beta accumulation African antibody Antibody titre antigenic antigenic drift antigenic profiles assessment Astra Zeneca Author B.1.351 B.1.617.1 B.1.617.2 bat bats Beta BNT162b2 BNT162b2 vaccines Booster vaccine booster vaccines ChAdOx1 changes in collected COVID-19 COVID19 death decrease decreases Delta delta variant dose effective Effectiveness Efficacy elicited evade expressed facilitate fold Fold changes glycoprotein groups hospitalisation Human human cell human cells humans Immunity India indicated individual Infection Lineage magnitude Mutation neutralisation neutralise Neutralising Antibodies neutralising antibody titres of BNT162b2 Pfizer Pfizer/BioNTech Prevent profile protective immune response pseudoviruses recipient recipients reduced reduction reduction in reductions reductions in required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera Severe infection shape significantly higher South South Africa spike glycoprotein spike glycoproteins Spike protein subsequent the spike protein titre vaccinated individuals vaccination Vaccine vaccine efficacy Vaccines variant variant B.1.617.2 variants variants of concern Viral viral variant Viral variants virus Virus spike VOCs while with infection with infections Wuhan Wuhan, China
[DOI] 10.1371/journal.ppat.1010022 PMC 바로가기 [Article Type] Research Article

Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

마우스-적응 된 SARS-COV-2는 치명적인 SARS-COV 도전으로부터 동물을 보호한다

Research Article

Published on 2021-11-042022-08-13
Journal: PLoS Biology
[Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome coronavirus antigenicity CMA3p20 coronavirus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 Critical cross-protection disease Economy element generate Heterologous heterologous challenge highlight human airway cell human airway cells human infection human SARS-CoV-2 strains Immune cell infiltration Immunity impair in vivo incorporation lack lung maintain mechanism Mouse models mouse-adapted SARS-CoV-2 mouse-adapted SARS-CoV-2 strains mouse-adapted strain mouse-adapted strain of SARS-CoV-2 Mutation natural infection offer overcome pandemic PROTECT public health Replication Research respiratory reverse genetic system robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Strains Vaccine variants variants of concern Viral viral replication
[DOI] 10.1371/journal.pbio.3001284 PMC 바로가기 [Article Type] Research Article

Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation

SARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.

407

Published on 2021-11-032022-08-13
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,

[키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407

Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial

청소년 및 노인의 SARS-COV-2 재조합 스파이크 단백질 백신 (NVX-COV2373)의 상이한 용량 요법 : 2 상 무작위 위약 대조 시험

Clinical Trial

Published on 2021-10-012022-08-13
Journal: PLoS Medicine
[Category] Biochemistry, MERS, SARS, 임상, 진단,

[키워드] 95% CI 95% confidence interval accumulate addition Administered Adults adverse events age Anti-spike Antibody Response assessments assigned composed conducted convalescent sera coronavirus Day dose dose regimen Efficacy Endpoint Enrollment exceeded Follow-up Formica Frequency full-length SARS-CoV-2 geometric mean geometric mean titer geometric mean titers GMTs group groups identify IgG immune persistence immune response immune responses immunogenic immunogenicity Immunoglobulin Immunoglobulin G include inhibitory concentration intensity intramuscular dose lack limitation Matrix-M1 adjuvant median Mild mild to moderate moderate neutralizing antibody Neutralizing antibody response neutralizing antibody responses NVX-CoV2373 occurred less Older Older adults participant Participants Phase 1 Phase 2 Placebo placebo-controlled placebo-controlled trial primary endpoints Protein Randomized randomized placebo-controlled trial Randomly reactogenicity receive Recombinant spike protein regimen researcher respiratory Respiratory Coronavirus robust safety follow-up SARS-CoV-2 second dose second vaccination secondary endpoint seroconversion rate seroconversion rates severity short duration spike glycoprotein spike glycoproteins Spike protein Support The United States These data Tolerability Treatment Trial Trial registration trimeric United States USA vaccination Vaccine vaccine group wild-type virus
[DOI] 10.1371/journal.pmed.1003769 PMC 바로가기 [Article Type] Clinical Trial

Development of ACE2 autoantibodies after SARS-CoV-2 infection

SARS-COV-2 감염 후 ACE2자가 항체의 발달

Research Article

Published on 2021-09-032022-08-13
Journal: PLoS ONE
[Category] Biochemistry, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] abundance ACE2 ACE2 antibody ACE2 protein Activation Ang II angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibodies antibody AT1 autoantibodies autoantibody cause cleave convalescent Cutoff decrease decreased activity detectable develop development enzyme enzyme activity exogenous ACE2 Hospitalized Hypothesis immune system implicated increase in Infection inhibit lead less mechanism Outpatient PASC Patient plasma positive PCR test proinflammatory Protein receptor resulting SARS-CoV-2 SARS-COV-2 infection serum soluble ACE2 Symptom tested threshold Trigger triggers
[DOI] 10.1371/journal.pone.0257016 PMC 바로가기 [Article Type] Research Article

Current status of therapeutic monoclonal antibodies against SARS-CoV-2

SARS-COV-2에 대한 치료 단일 클론 항체의 현재 상태

Pearls

Published on 2021-09-032022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 진단,

[키워드] current monoclonal antibody SARS-CoV-2 therapeutic
[DOI] 10.1371/journal.ppat.1009885 PMC 바로가기 [Article Type] Pearls

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19

COVID-19 예후 평가를위한 바이오 마커로서의 D-Dimer : COVID-19를 가진 입원 환자에서 입원 및 질병 결과를 예측하는 데있어서 D-Dimer 수준.

Research Article

Published on 2021-08-262022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 바이오마커,

[키워드] 95% CI Accuracy adjusted Admission age an area analyzed Biomarker calculate characteristic clinical confirmed COVID-19 case coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 patients Cox proportional hazard Cox proportional hazards regression analysis Cutoff cutoff value D-dimer D-dimer level D-dimer value determine died dimer disease Elevation fibrinogen Fibrinogen Equivalent Unit hazard ratio hospital Hospital mortality Hospital stay hospitalized patient hospitals in Kathmandu immunofluorescence assay laboratory parameter Laboratory parameters Mortality on admission outcome Patient patients with COVID-19 poor prognosis predict Predictive Predictive value Prognosis receiver operating characteristic receiver operating characteristic curve recorded regression analysis reported respiratory Respiratory illness Result ROC Curve sensitivity specificity surviving patient surviving patients thrombotic disorders two group two groups was measured was used with COVID-19
[DOI] 10.1371/journal.pone.0256744 PMC 바로가기 [Article Type] Research Article