As the pandemic continues, individuals with re-detectable positive (RP) SARS-CoV-2 viral RNA among recovered COVID-19 patients have raised public health concerns. It is imperative to investigate whether the cases with re-detectable positive (RP) SARS-CoV-2 might cause severe infection to the vulnerable population. In this work, we conducted a systematic review of recent literature to investigate reactivation and reinfection among the discharged COVID-19 patients that are found positive again. Our study, consisting more than a total of 113,715 patients, indicates that the RP-SARS-CoV-2 scenario occurs plausibly due to reactivation, reinfection, viral shedding, or testing errors. Nonetheless, we observe that previously infected individuals have significantly lower risk of being infected for the second time, indicating that reactivation or reinfection of SARS-CoV-2 likely have relatively less impact in the general population than the primary infection.
【저자키워드】 COVID-19, pandemic, Reinfection, Reactivation, Re-detectable positive, 【초록키워드】 public health, SARS-CoV-2, Severe infection, viral shedding, systematic review, risk, Reactivation, Viral, Viral RNA, General population, patients, Primary infection, Recovered COVID-19 patients, SARS-CoV-2 viral RNA, COVID-19 patient, vulnerable population, infected individual, individual, positive, significantly lower, recovered COVID-19 patient, observé, raised, conducted, indicate, less, occur, imperative, discharged, 【제목키워드】 review, respiratory,