Background Novel mRNA vaccines provide a high degree of protection against COVID-19 infection, hospitalisation, and death. However, no vaccine claimed 100% effectiveness and it is expected that a small proportion of vaccinated individuals may develop a breakthrough infection. There is a concern relating to the ability of variants to evade vaccine-induced immunity that leads to asymptomatic infection or occasionally progress to disease. The extent of this ability is largely unknown. Case Report An 88-year-old male patient was brought to the emergency department on July 25, 2021, with a presentation of a lower respiratory tract infection. He was screened for SARS-CoV-2, and tested positive for the reverse transcription-polymerase chain reaction (RT-PCR) test for SARS-CoV-2. According to the patient, he was diagnosed with benign prostatic hyperplasia (BPH) after a prostate biopsy in 2015 but, at the time of admission, he was not taking any chronic medication. He received the first dose (batch no. FA7812) of the Pfizer-Biotech vaccine on June 8, 2021, and the second dose (batch no. FE2090) on July 20, 2021. He was admitted to the isolation ward with a diagnosis of vaccine breakthrough COVID-19 infection and BPH. Conclusion This case report highlights the issue of vaccine breakthrough infections and the potential risk of contracting the COVID-19 disease despite successfully receiving two doses of the Pfizer-BioNTech vaccine six weeks apart.
【저자키워드】 COVID-19, SARS-CoV-2, mRNA vaccine, vaccine effectiveness, Pfizer-BioNTech, 【초록키워드】 Vaccine, variant, Infection, respiratory tract infection, Diagnosis, RT-PCR, variants, Case report, emergency department, COVID-19 disease, polymerase chain reaction, COVID-19 infection, male, Patient, asymptomatic infection, Effectiveness, Isolation, death, reverse transcription, Breakthrough infection, novel, respiratory, medication, hospitalisation, disease, Admission, Pfizer-BioNTech, Prostate, Reverse transcription-polymerase chain reaction, lower respiratory tract infection, dose, vaccine breakthrough infections, Vaccine-induced immunity, Lower respiratory tract, leads, Chain Reaction, benign prostatic hyperplasia, second dose, first dose, potential risk, vaccinated individuals, issue, report, positive, vaccinated individual, vaccine breakthrough infection, highlight, tested, develop, proportion, the patient, diagnosed, receiving, screened, evade, expected, claimed, 【제목키워드】 report,