Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health organization (WHO) in March 2020, just a few weeks after being described for the first time. Since then, global research effort has considerably increased humanity’s knowledge about both viruses and disease. It has also spawned several vaccines that have proven to be key tools in attenuating the spread of the pandemic and severity of COVID-19. However, with vaccine-related skepticism being on the rise, as well as breakthrough infections in the vaccinated population and the threat of a complete immune escape variant, alternative strategies in the fight against SARS-CoV-2 are urgently required. Calcium signals have long been known to play an essential role in infection with diverse viruses and thus constitute a promising avenue for further research on therapeutic strategies. In this review, we introduce the pivotal role of calcium signaling in viral infection cascades. Based on this, we discuss prospective calcium-related treatment targets and strategies for the cure of COVID-19 that exploit viral dependence on calcium signals.
【저자키워드】 SARS-CoV-2, Therapeutics, viral infections, calcium, Ca2+ channels, 【초록키워드】 COVID-19, Treatment, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, viral infection, Coronavirus disease 2019, Vaccine, coronavirus, pandemic, knowledge, variant, Infection, Respiratory illness, severe acute respiratory syndrome Coronavirus, virus, Spread, Viral, Immune escape, severity of COVID-19, Research, Therapeutic strategies, breakthrough infections, target, WHO, Breakthrough infection, RNA virus, respiratory, disease, calcium, cure, Health Organization, World Health Organization, acute respiratory syndrome, Calcium signaling, acute respiratory syndrome coronavirus, both viruses, effort, cascades, skepticism, Complete, described, required, in viral, cause, both virus, positive-sense single-stranded RNA, 【제목키워드】 calcium, signal, Potential, Assessing,