Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 patients upon intensive care unit (ICU) admission. Thirty-eight critically ill COVID-19 patients were included in this observational study, 10 of whom died in the ICU. Endothelial biomarkers, including soluble (s)E-selectin, sP-selectin, angiopoietin 1 and 2 (Ang-1 and Ang-2, respectively), soluble intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF), soluble vascular endothelial (VE)-cadherin, and von Willebrand factor (vWf), were measured upon ICU admission. The ICU cohort was subsequently divided into survivors and non-survivors; Kaplan–Meier analysis was used to explore associations between biomarkers and survival, while receiver operating characteristic (ROC) curves were generated to determine their potential prognostic value. sE-selectin, sP-selectin, Ang-2, and sICAM-1 were significantly elevated in ICU non-survivors compared to survivors, and also associated with a higher mortality probability in the Kaplan–Meier analysis. The prognostic values of sE-selectin, Ang-2, and sICAM-1 from the generated ROC curves were greater than 0.85. Hence, we conclude that in our cohort, ICU non-survivors had higher levels of specific endothelial markers compared to survivors. Elevated levels of these markers upon ICU admission could possibly predict mortality in COVID-19.
【저자키워드】 COVID-19, Mortality, endotheliopathy, angiopoietin, sE-selectin, sP-selectin, sICAM-1, 【초록키워드】 Biomarker, Biomarkers, intensive care, endotheliopathy, intensive care unit, endothelial damage, E-selectin, hospitalized patients, observational study, ICU, angiopoietin, Probability, Cohort, survival, Critically ill, Survivors, ROC, Endothelial markers, ICU admission, von Willebrand factor, characteristic, Admission, predict, association, marker, COVID-19 patient, ROC Curve, critically ill COVID-19 patients, receiver operating characteristic, intercellular adhesion molecule, Adhesion Molecule, vascular endothelial growth factor, endothelial, Prognostic value, Vascular, VEGF, growth factor, selectin, survivor, Ang-1, Kaplan–Meier analysis, non-survivor, greater, was used, died, significantly, involved, elevated, determine, suggested, were measured, endothelial marker, intercellular, were assessed, 【제목키워드】 ICU, Level, Ill,