The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
All Keywords
【저자키워드】 SARS-CoV-2, coronavirus, flavonoids, TPC channels, plant vacuole, mammalian endolysosome, 【초록키워드】 COVID-19, Tumor, Coronavirus infection, pandemic, Diseases, progression, flavonoid, mechanism, naringenin, plague, rationale, solid tumor, blocker, pharmacological, effective, shown, impairing, 【제목키워드】 naringenin, channel, role,
【저자키워드】 SARS-CoV-2, coronavirus, flavonoids, TPC channels, plant vacuole, mammalian endolysosome, 【초록키워드】 COVID-19, Tumor, Coronavirus infection, pandemic, Diseases, progression, flavonoid, mechanism, naringenin, plague, rationale, solid tumor, blocker, pharmacological, effective, shown, impairing, 【제목키워드】 naringenin, channel, role,
감귤류 과일과 토마토에 존재하는 플라보노이드 나린제닌(Nar)은 인간 세포 내 채널의 새로운 부류, 즉 TPC(two-pore channel) 계열의 차단제로 확인되었으며, 그의 역할은 여러 질병에서 확립되었습니다. 실제로 Nar는 TPC 활성을 구체적으로 손상시켜 고형 종양 진행에 필수적인 과정인 신생혈관형성에 효과적인 것으로 나타났습니다. 현재 검토의 목표는 TPC 채널을 코로나바이러스 감염 메커니즘에 연결하는 근거와 Nar에 의한 억제가 현재의 전염병 전염병 COVID-19와 싸우기 위한 효율적인 약리학적 전략이 될 수 있는 방법을 설명하는 것입니다.