CoronaVac vaccine from Sinovac Life Science is currently being used in several countries. In Chile, the effectiveness of preventing hospitalization is higher than 80% with a vaccination schedule. However, to date, there are no data about immune response induction or specific memory. For this reason, we recruited 15 volunteers without previous suspected/diagnosed COVID-19 and with negative PCR over time to evaluate the immune response to CoronaVac 28 and 90 days after the second immunization (dpi). The CoronaVac administration induces total and neutralizing anti-spike antibodies in all vaccinated volunteers at 28 and 90 dpi. Furthermore, using ELISpot analysis to assay cellular immune responses against SARS-CoV-2 spike protein, we found an increase in IFN-gamma- and Granzyme B-producing cells in vaccinated volunteers at 28 and 90 dpi. Together, our results indicate that CoronaVac induces a robust humoral immune response and cellular immune memory of at least 90 dpi.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Neutralizing antibodies, CoronaVac, Immunological memory, herd immunity, 【초록키워드】 immune response, Hospitalization, Cellular immune response, CoronaVac, immunization, Spike protein, memory, immune responses, SARS-CoV-2 spike protein, Effectiveness, Neutralizing, immune memory, ELISPOT, humoral immune response, anti-spike antibodies, Sinovac, anti-spike antibody, IFN-gamma, cellular, administration, granzyme B, Analysis, life, Science, Negative PCR, cellular immune responses, granzyme, vaccination schedule, Volunteer, Cell, robust, evaluate, recruited, increase in, induce, 【제목키워드】 Population, response, group, induced, schedule,