Various metabolites identified with therapeutic mushrooms have been found from different sources and are known to have antibacterial, antiviral, and anticancer properties. Over thousands soil growth-based mushroom metabolites have been discovered, and utilized worldwide to combat malignancy. In this study, psilocybin-mushroom that contains the psychedelic compounds such as psilacetin, psilocin, and psilocybine were screened and found to be inhibitors of SARS-CoV-2 Mprotease. It has been found that psilacetin, psilocin, and psilocybine bind to Mprotease with −6.0, −5.4, and −5.8 kcal/mol, respectively. Additionally, the psilacetin was found to inhibit human interleukin-6 receptors to reduce cytokine storm. The binding of psilacetin to Mprotease of SARS-CoV-2 and human interleukin-6 receptors changes the structural dynamics and Gibbs free energy patterns of proteins. These results suggested that psilocybin-mushroom could be utilized as viable potential chemotherapeutic agents for SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, psilocybin, Mprotease, metabolite, mushroom, 【초록키워드】 Cytokine storm, Antiviral, interleukin-6, cytokine, Proteins, inhibitors, free energy, therapeutic, Antibacterial, change, psilocybin, binding, interleukin-6 receptor, malignancy, chemotherapeutic agents, Gibbs free energy, psilocybine, inhibitors of SARS-CoV-2, Compound, anticancer, over, psilocin, chemotherapeutic agent, inhibit, screened, suggested, reduce, 【제목키워드】 Human, drug, psilocybin, derivative, storm, Against,