Following respiratory viral infections or local immunizations, lung resident-memory T cells (T RM ) of the CD8 lineage provide protection against the same pathogen or related pathogens with cross-reactive T cell epitopes. Yet, it is now clear that, if homeostatic controls are lost following viral pneumonia, CD8 T RM cells can mediate pulmonary pathology. We recently showed that the aging process can result in loss of homeostatic controls on CD8 T RM cells in the respiratory tract. This may be germane to treatment modalities in both influenza and coronavirus disease 2019 (COVID-19) patients, particularly, the portion that present with symptoms linked to long-lasting lung dysfunction. Here, we review the developmental cues and functionalities of CD8 T RM cells in viral pneumonia models with a particular focus on their capacity to mediate heterogeneous responses of immunity and pathology depending on immune status.
【저자키워드】 pathology, Influenza, Viral pneumonia, age, resident memory, homeostasis, 【초록키워드】 COVID-19, Treatment, coronavirus disease, pathology, Coronavirus disease 2019, Immunity, Pneumonia, T cells, Influenza, lung, Local, Symptom, CD8, Viral pneumonia, Epitopes, T cell, Viral, pathogen, Lineage, Control, Pathogens, respiratory tract, respiratory, patients, respiratory viral infection, respiratory viral infections, Immune status, cross-reactive, T cell epitopes, Pulmonary pathology, aging process, portion, lung dysfunction, heterogeneous responses, Cell, in viral, long-lasting, developmental, heterogeneous response, homeostatic, 【제목키워드】 COVID-19, T cells, Dynamics, CD8,