Objectives The coordinated immune response of the host is the key of the successful combat of the body against SARS-CoV-2 infection and is decisive for the development and progression of COVID-19. In this study, we aimed to investigate whether the immunological phenotype of patients are associated with duration of illness in patients with severe COVID-19. Method In this single-center study, 69 patients with severe or critical COVID-19 were recruited retrospectively. Immunological parameters including counts of white blood cells, neutrophils, lymphocytes, the neutrophil-to-lymphocyte ratio, and levels of circulating cytokines and cytokine receptors were screened for their association with disease severity, survival and duration of illness of COVID-19. Results Our data confirmed previous results that neutrophil-to-lymphocyte ratio and circulating levels of IL-6 represent prominent biomarker for the prediction of disease severity and survival of COVID-19. However, this study shows for the first time that duration of illness in patients with severe COVID-19 is positively associated with serum levels of IL-8 ( P =0.004) and soluble IL-2Rα ( P =0.025). Conclusion The significant association of duration of illness with circulating levels of IL-8 and soluble IL-2Rα in patients with severe COVID-19 implicates that neutrophils and T cells are involved in the evolution of COVID-19.
【저자키워드】 Coronavirus disease 2019, interleukin 6, interleukin 8, soluble interleukin 2 receptor, neutrophil-to-lymphocytes ratio, severe acute respiratory syndrome coronavirus−2, 【초록키워드】 COVID-19, Neutrophils, Evolution, immune response, Biomarker, Cytokines, Lymphocytes, severe COVID-19, T cells, IL-6, SARS-COV-2 infection, disease severity, neutrophil, Blood cells, cytokine, progression, Neutrophil-to-lymphocyte ratio, lymphocyte, T cell, survival, Patient, IL-8, Critical, association, White blood cells, Serum level, serum levels, immunological phenotype, single-center study, circulating, cytokine receptor, circulating cytokines, immunological parameters, parameter, Host, objective, Result, involved, recruited, screened, circulating cytokine, duration of illness, 【제목키워드】 COVID-19, Prolonged, Level, illness,