There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long-term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID-19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS-CoV-2 spike 1 receptor-binding domain (S1-RBD), spike 2 extracellular domain (S2-ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N-IgA rose most rapidly in the early stage of infection, while S2-IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID-19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS-CoV-2.
【저자키워드】 SARS-CoV-2, Neutralizing antibodies, spike glycoprotein, nucleocapsid protein, Receptor binding domain, immunoreaction, 【초록키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, antibodies, IgM, Coronavirus disease 2019, coronavirus, vaccination, Hospitalized, Immunity, antibody, Antibody Response, Infection, severe acute respiratory syndrome Coronavirus, nucleocapsid protein, Neutralizing activity, Receptor-binding domain, Screen, Immunoglobulin, Patient, target, targets, respiratory, characteristic, early stage, SARS-CoV-2 spike, Postinfectious, observation, acute respiratory syndrome, acute respiratory syndrome coronavirus, reaction, worldwide pandemic, domain, IgA levels, serum sample, detective, effective, Extracellular, described, collected, remained, onset of symptom, quantified, IgA level, offered, POS, 【제목키워드】 dynamic,