The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website ( https://bix.unil.ch/covid/ ). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Influenza, immune profiling, whole blood transcriptome, RNA-sequencing, 【초록키워드】 Neutrophils, T cells, Influenza, SARS-COV-2 infection, severity, COVID-19 severity, NK cells, Toxicity, Blood cells, Symptom, host response, metabolism, cell cycle, adverse outcomes, adverse outcome, B cell, COVID-19 pathogenesis, Immunoglobulin, Patient, Complication, influenza viruses, IFN, group, transcriptomic profile, Evidence, distress, dysregulation, blood cell, respiratory distress, reduction, website, infected individuals, life-threatening, reason, over-expression, dramatic increase, transcriptomic profiles, degranulation, Complete, transcriptomic, responses, feature, Cell, dysregulation of T cells, immune signature, develop, involved, healthy, provided, individuals, dysregulated, Increasing, gene expression pattern, individuals with COVID-19, infected with SARS-CoV-2, 【제목키워드】 Influenza, signature, difference,