The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, TMPRSS2, Cytokine storm, epigenetics, pro-inflammatory cytokines, multi-organ, 【초록키워드】 coronavirus disease, viruses, Coronavirus disease 2019, coronavirus, severe COVID-19, SARS-COV-2 infection, COVID-19 pandemic, Genetic, Infection, progression, severe acute respiratory syndrome Coronavirus, survival, Viral, viral replication, management, therapeutic, severe cases, Clinical significance, understanding, mechanisms, DNA methylation, respiratory, Epigenetic, clinical phenotype, histone, clinical manifestation, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, environmental factors, clinical phenotypes, chromatin, host genome, event, highlight, resulting, virus, involved, occur, driven by, respond, alterations, with COVID-19, 【제목키워드】 clinical, MARK,