Coronavirus disease 2019 (COVID-19) is a newly emerged disease with various clinical manifestations and imaging features. The diagnosis of COVID-19 depends on a positive nucleic acid amplification test by real-time reverse transcription-polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the clinical manifestations and imaging features of COVID-19 are non-specific, and nucleic acid test for SARS-CoV-2 can have false-negative results. It is presently believed that detection of specific antibodies to SARS-CoV-2 is an effective screening and diagnostic indicator for SARS-CoV-2 infection. Thus, a combination of nucleic acid and specific antibody tests for SARS-CoV-2 will be more effective to diagnose COVID-19, especially to exclude suspected cases.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, nucleic acid, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, SARS-COV-2 infection, diagnostic, severe acute respiratory syndrome Coronavirus, RT-PCR, clinical manifestations, polymerase chain reaction, nucleic acid, Features, antibody tests, nucleic acid test, Antibody test, respiratory, nucleic acid amplification, false-negative results, disease, false-negative, non-specific, diagnose, specific antibodies, Reverse transcription-polymerase chain reaction, Combination, Chain Reaction, clinical manifestation, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, real-time reverse transcription-polymerase chain reaction, false, positive, feature, effective, specific antibody, diagnosis of COVID-19, 【제목키워드】 Coronavirus disease 2019, antibody tests, Antibody test, Combination,