Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initiates the infection process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through the receptor-binding domain (RBD) in the S1 subunit of the viral spike (S) protein. This event is followed by virus–cell membrane fusion mediated by the S2 subunit, which allows virus entry into the host cell. Therefore, the SARS-CoV-2 S protein is a key therapeutic target, and prevention and treatment of coronavirus disease 2019 (COVID-19) have focused on the development of neutralizing monoclonal antibodies (nAbs) that target this protein. In this review, we summarize the nAbs targeting SARS-CoV-2 proteins that have been developed to date, with a focus on the N-terminal domain and RBD of the S protein. We also describe the roles that binding affinity, neutralizing activity, and protection provided by these nAbs play in the prevention and treatment of COVID-19 and discuss the potential to improve nAb efficiency against multiple SARS-CoV-2 variants. This review provides important information for the development of effective nAbs with broad-spectrum activity against current and future SARS-CoV-2 strains.
【저자키워드】 COVID-19, SARS-CoV-2, viral infection, neutralization, Immunotherapy, monoclonal antibodies, Spike protein, 【초록키워드】 Treatment, coronavirus disease, Coronavirus disease 2019, S protein, severe acute respiratory syndrome coronavirus-2, severe acute respiratory syndrome Coronavirus, angiotensin-converting enzyme 2, binding affinity, Severe acute respiratory syndrome, Protein, Neutralizing activity, Viral, Receptor-binding domain, SARS-CoV-2 variants, RBD, virus entry, membrane fusion, respiratory, information, S2 subunit, neutralizing monoclonal antibodies, neutralizing monoclonal antibody, NAb, binding, SARS-CoV-2 S protein, N-terminal domain, Coronavirus-2, S1 subunit, angiotensin, SARS-CoV-2 proteins, Efficiency, therapeutic target, followed by, focus, host cell, acute respiratory syndrome, treatment of COVID-19, acute respiratory syndrome coronavirus, infection process, NAbs, SARS-CoV-2 strains, viral spike, SARS-CoV-2 protein, cellular receptor, effective, IMPROVE, the S1 subunit, provided, provide, the receptor-binding domain, the S protein, initiate, the SARS-CoV-2, 【제목키워드】 Treatment, antibody,