Since the beginning of the COVID-19 pandemic, multiple SARS-CoV-2 variants have emerged. While some variants spread only locally, others, referred to as variants of concern, disseminated globally and became drivers of the pandemic. All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic, and mutations in the viral spike (S) protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response. As a consequence, mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies. Furthermore, mutations in the S protein can modulate viral transmissibility and pathogenicity.
【저자키워드】 immunology, SARS-CoV-2, Delta, Cell Biology, AY.4.2, Host cell entry, Antibody evasion, 【초록키워드】 pandemic, Mutation, S protein, Neutralizing antibodies, COVID-19 pandemic, variant, SARS-CoV-2 variant, variants of concern, virus, variants, Spread, Protein, Viral, Transmissibility, SARS-CoV-2 variants, pathogenicity, Neutralizing antibody response, referred to, host cell, Drivers, circulating, viral spike, while, modulate, the S protein, driver, 【제목키워드】 antibody, Evidence, cell entry,