Abstract
Neutralizing antibodies against SARS-CoV-2 are important to protect against infection and/or disease. Using an assay to detect antibodies directed against the receptor binding domain (RBD) of SARS-CoV-2 Spike, we identified individuals with SARS-CoV-2 infection after an outbreak at a local health institution. All but one COVID-19 patient developed detectable anti-RBD antibodies and 77% had virus neutralizing antibody titers of >1:25. Antibody levels declined slightly over time. However, we still detected virus neutralizing antibody titers in 64% of the COVID-19 patients at >300 days after infection, demonstrating durability of neutralizing antibody levels after infection. Importantly, full COVID-19 vaccination of these individuals resulted in higher antibody titers compared to fully vaccinated individuals in the absence of prior infection. These data demonstrate long-lived antibody-mediated immunity after SARS-CoV-2 infection, and a clear benefit of two vaccine doses for recovered individuals.
Keywords: SARS-CoV-2 ⋅ COVID-19 ⋅ Vaccines ⋅ antibody titers ⋅ waning immunity.
【저자키워드】 SARS-CoV-2 ⋅ COVID-19 ⋅ Vaccines ⋅ antibody titers ⋅ waning immunity., 【초록키워드】 COVID-19, neutralizing antibody, SARS-CoV-2, Immunity, Neutralizing antibodies, spike, antibody, SARS-COV-2 infection, Infection, Local, virus, Receptor binding domain, vaccine dose, COVID-19 vaccination, outbreak, RBD, Antibody titer, antibody levels, disease, COVID-19 patients, Antibody titers, antibody level, Neutralizing antibody titer, SARS-CoV-2 spike, COVID-19 patient, Antibody-mediated immunity, waning immunity, Anti-RBD antibody, These data, individual, Anti-RBD antibodies, vaccinated individual, benefit, health institution, PROTECT, detect, detectable, absence, individuals, declined, 【제목키워드】 vaccination, Antibody Response, Antibody titer,