Abstract
We aimed to analyze the efficacy and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV (PLWH). A total of 143 PLWH and 50 healthy individuals were included in this study. A commercially available magnetic chemiluminescence enzyme immunoassay kit was used to detect serum IgG and IgM antibodies against SARS-CoV-2. Serum levels of SARS-CoV-2-specific IgG were significantly higher in the control group than in the PLWH group (p = 0.001). Overall, 76% of individuals in the control group were detected with seropositivity IgG against SARS-CoV-2 compared to 58% in the PLWH group (p = 0.024). In PLWH with IgG seropositivity, CD4+ T-cell counts before antiretroviral therapy (ART) was higher (p = 0.015). Multivariable analysis indicated that CD4+ T cells at IgG detection (odds ratio [OR] = 1.004, p = 0.006) and time after vaccination (OR = 0.977, p = 0.014) were independently associated with seropositivity IgG against SARS-CoV-2 in PLWH. Neutralizing antibody (nAb) titers in PLWH against wild-type SARS-CoV-2 were similar to those in the control group (p = 0.160). The proportion of seropositive nAbs against wild-type SARS-CoV-2 was also similar (95% in the control group vs. 97% in the PLWH group, p = 0.665). Similar results were obtained when nAb was detected against the delta variants with similar titers (p = 0.355) and a similar proportion of seropositive nAbs were observed (p = 0.588). All the side effects observed in our study were mild and self-limiting. The inactivated COVID-19 vaccine appears to be safe with good immunogenicity in Chinese PLWH.
Keywords: COVID-19; SARS-CoV-2 vaccination; human immunodeficiency virus; neutralizing antibody; side effects.
【저자키워드】 COVID-19, neutralizing antibody, side effects., Human immunodeficiency virus, SARS-CoV-2 vaccination, 【초록키워드】 neutralizing antibody, SARS-CoV-2, IgG, COVID-19 vaccine, vaccination, antibody, T cells, immunodeficiency, delta variant, SARS-CoV-2 vaccine, immunoassay, IgM antibodies, Antiretroviral therapy, ART, Seropositivity, Mild, CD4+ T cells, Efficacy and safety, Neutralizing, enzyme immunoassay, Side effects, Human immunodeficiency virus, chemiluminescence, seropositive, CD4+ T cell, PLWH, SARS-CoV-2 vaccination, inactivated, NAb, Delta variants, Analysis, Odds ratio, titers, Safe, Side effect, control group, enzyme, IgM antibody, serum levels, individual, self-limiting, multivariable analysis, Chinese, wild-type SARS-CoV-2, serum IgG, SARS-CoV-2-specific IgG, CD4+ T-cell, was used, detect, proportion, indicated, appear, significantly higher, healthy individual, with HIV, 【제목키워드】 immunogenicity, cross-sectional, SARS-CoV-2 vaccine, inactivated,