Abstract
Background: Antiviral drugs have shown little impact in patient infected with acute respiratory coronavirus 2 (SARS-CoV-2). Especially for immunocompromised persons positive for SARS-CoV-2, novel treatments are warranted. Recently, the U.S. FDA has granted an emergency use authorization (EUA) to two monoclonal antibodies (mAb) targeting the viral spike protein: bamlanivimab and casivirimab and imdevimab. As per the EUA, all SARS-CoV-2 positive organ transplant recipients can receive mAb treatment. Patients and methods: We queried our center’s transplant registry to identify SARS-CoV-2 infected recipients treated with single doses of either Bamlanivimab or casivirimab/imdevimab up to May 31, 2021. We analyzed clinical outcomes, renal function and virus-specific antibodies. The co-primary endpoints were hospitalization due to COVID-19 and SARS-CoV-2 RT-PCR negativity. Results: Thirteen patients at a median interval of 55 (IQR, 26-110) months from transplant were treated: 8 with bamlanivimab and 5 with casivirimab/imdevimab. In all, 4/13 (31%) patients were hospitalized at some time, while 11/13 (85%) achieved PCR negativity. 2/4 hospitalized patients received mAb as rescue treatment. Overall mortality was 23%, with one death attributable to transplant-associated lymphoma. All six patients infected with the B 1.1.7 variant were alive at last contact. Conclusion : mAb treatment appears effective when administered early to SARS-CoV-2-infected transplant recipients.
Keywords: SARS-CoV-2; bamlanivimab; immunosuppression; kidney transplantation; monoclonal antibodies.
【저자키워드】 SARS-CoV-2, Immunosuppression, bamlanivimab, Kidney transplantation, monoclonal antibodies., 【초록키워드】 COVID-19, Treatment, antibodies, coronavirus, Hospitalized, Mortality, Hospitalization, monoclonal antibody, antiviral drugs, variant, Immunosuppression, Organ transplant, drug, monoclonal antibodies, Emergency use authorization, renal function, clinical outcomes, bamlanivimab, EUA, Spike protein, kidney, Viral, Transplant, Imdevimab, lymphoma, Patient, death, Immunocompromised, SARS-CoV-2 RT-PCR, respiratory, single dose, mAb, Contact, viral spike protein, overall mortality, recipients, PCR negativity, viral spike, negativity, median interval, positive, recipient, virus-specific antibodies, Administered, effective, Respiratory Coronavirus, co-primary endpoints, single doses, U.S. FDA, shown, analyzed, identify, treated, appear, hospitalized patient, receive, co-primary endpoint, IQR, 【제목키워드】 experience, recipient, Combined,