Abstract
Background: The prompt detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important in the therapeutic management of infected patients. Rapid diagnostic tests are widely used for this purpose. This study aimed to evaluate the clinical performance of four SARS-CoV-2 immunoglobulin IgG/IgM rapid diagnostic tests in the detection of SARS-CoV-2.
Methods: Nasopharyngeal and oropharyngeal swabs and/or sputum were collected from 30 patients infected with SARS-CoV-2 and 30 healthy volunteers. All specimens were tested using four SARS-CoV-2 IgG/IgM rapid diagnostic tests and real-time polymerase chain reaction. We assessed the clinical sensitivity and specificity of the tests.
Results: The clinical sensitivity of FREND™, SsmarTest™, BIOCREDIT™, and IVDLAB™ was 96.67%, 100.00%, 100.00%, and 96.67%, respectively, compared to real-time polymerase chain reaction. The clinical specificity was 96.67%, 100.00%, 86.67%, and 96.67%, respectively.
Conclusion: These findings could expedite the detection of SARS-CoV-2 and thus reduce the risk of further transmission of the virus.
Keywords: SARS-CoV-2; SARS-CoV-2 IgG/IgM antibody; rapid antibody test; rapid diagnostic test; sensitivity; specificity.
【저자키워드】 SARS-CoV-2, rapid antibody test, sensitivity, Rapid diagnostic test, specificity., SARS-CoV-2 IgG/IgM antibody, 【초록키워드】 rapid antibody test, coronavirus, antibody, diagnostic test, diagnostic, risk, Transmission, severe acute respiratory syndrome Coronavirus, sputum, virus, polymerase chain reaction, specificity, Immunoglobulin, Rapid diagnostic test, nasopharyngeal, diagnostic tests, oropharyngeal swab, management, real-time polymerase chain reaction, swabs, therapeutic, Patient, Rapid, Antibody test, respiratory, clinical sensitivity, Chain Reaction, acute respiratory syndrome, acute respiratory syndrome coronavirus, infected patients, acute respiratory syndrome coronavirus 2, healthy volunteers, IgM antibody, clinical specificity, specimen, polymerase chain, tested, collected, evaluate, reduce, infected with SARS-CoV-2, 【제목키워드】 performance, acute respiratory syndrome,