Abstract
To investigate the clinical characteristic of domestic coronavirus disease 2019 (COVID-19) patients after vaccination campaign conducted in China. According to vaccination status and months from first vaccine dose to infection detection, patients were divided into unvaccinated, <3 months, 3-6 months, and >6 months groups. The information of demographic and clinical characteristics, laboratory and thoracic computed tomography (CT) findings, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid and IgM, IgG antibodies was retrospectively collected. Therapeutic approaches, temperature-normalizing and viral shedding times, outcomes were also summarized. SARS-CoV-2 antibody levels were further analyzed based on the other following variables: time from second vaccine dose to infection, vaccine dose, the interval from the first to the second dose, and vaccine brand. Among 208 COVID-19 patients, 13 (6.28%) were unvaccinated. No significant differences in demographic and clinical characteristics, laboratory and CT findings, and SARS-CoV-2 nucleic acid loads were detected between groups (all p > 0.05). In comparison with the unvaccinated group, the median SARS-CoV-2 IgG levels were noticeably increased in those vaccinated groups (0.603 in unvaccinated, 15.925 in <3 months, 14.04 in 3-6 months, and 4.94 in >6 months, respectively, p < 0.05). However, SARS-CoV-2 IgG levels were not altered between groups divided based on the other variables. Vaccination does not affect the clinical characteristics in COVID-19 patients. COVID-19 patients with vaccination have high SARS-CoV-2 IgG levels. Underscore the necessity of rapid implementation of vaccination campaigns can be speculated.
Keywords: COVID-19; IgG; SARS-CoV-2; clinical characteristic; vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, vaccination., clinical characteristic, 【초록키워드】 coronavirus disease, IgM, Coronavirus disease 2019, Vaccine, coronavirus, vaccination, Clinical characteristics, Infection, viral shedding, outcome, severe acute respiratory syndrome Coronavirus, Laboratory, vaccine dose, China, Computed tomography, nucleic acid, IgG antibody, Viral, SARS-CoV-2 antibody, IgG antibodies, implementation, Patient, temperature, respiratory, group, information, characteristic, SARS-CoV-2 IgG, COVID-19 patients, Thoracic, COVID-19 patient, Vaccination Status, not altered, acute respiratory syndrome, significant difference, no significant differences, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, therapeutic approaches, approaches, second dose, IgG levels, CT findings, SARS-CoV-2 nucleic acid, demographic and clinical characteristics, other variables, analyzed, collected, conducted, not affect, groups, the median, Underscore, 【제목키워드】 clinical,