Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic. Here, we present non-human primate immunogenicity and protective efficacy data generated with the capsid virus-like particle (cVLP)-based vaccine ABNCoV2 that has previously demonstrated immunogenicity in mice. In rhesus macaques, a single vaccination with either 15 or 100 μg ABNCoV2 induced binding and neutralizing antibodies in a dose-dependent manner, at levels comparable to those measured in human convalescents. A second vaccine administration led to a >50-fold increase in neutralizing antibodies, with 2-log higher mean levels in the 100-μg ABNCoV2 group compared with convalescent samples. Upon SARS-CoV-2 challenge, a significant reduction in viral load was observed for both vaccine groups relative to the challenge control group, with no evidence of enhanced disease. Remarkably, neutralizing antibody titers against an original SARS-CoV-2 isolate and against variants of concern were comparable, indicating a potential for broad protection afforded by ABNCoV2, which is currently in clinical testing.
Keywords: COVID-19; SARS-CoV-2; broad neutralizing antibodies; corona; non-human primates (NHP); protection; variants of concern (VOCs); virus-like particles (VLP).
【저자키워드】 COVID-19, SARS-CoV-2, protection, Corona, variants of concern (VOCs), broad neutralizing antibodies, non-human primates (NHP), virus-like particles (VLP)., 【초록키워드】 severe acute respiratory syndrome coronavirus 2, neutralizing antibody, Efficacy, Vaccine, coronavirus, immunogenicity, Neutralizing antibodies, variants of concern, severe acute respiratory syndrome Coronavirus, variants, Viral, Corona, Viral load, mice, non-human primates, VOCs, Neutralizing, respiratory, convalescent, virus-like particles, non-human primate, disease, Antibody titers, VLP, Neutralizing antibody titer, Protective, binding, rhesus macaques, Evidence, evidence of, no evidence of, acute respiratory syndrome, Virus-like particle, control group, acute respiratory syndrome coronavirus, dose-dependent manner, neutralizing antibody titers, worldwide pandemic, clinical testing, binding and neutralizing antibodies, vaccine administration, single vaccination, vaccine group, caused, demonstrated, increase in, comparable, reduction in, 【제목키워드】 macaque, capsid, Level,