Abstract
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.
Keywords: IgA; NFκB-deficiency; breast milk; immunosuppression; persistent SARS-CoV-2 infection.
【저자키워드】 Immunosuppression, IgA, breast milk, NFκB-deficiency, persistent SARS-CoV-2 infection., 【초록키워드】 COVID-19, Treatment, SARS-CoV-2, IgG, antibody, SARS-COV-2 infection, variant, Infection, Immunosuppression, Symptom, Clinical course, Immunoglobulin, cells, respiratory virus, breast milk, Patient, Gamma, plasma, Neutralizing, virus infection, respiratory, mother, mucosa, deficiency, oral route, infected patients, IgA antibodies, secretion, treat, NFκB, effective, immunodeficient patients, robust, tested, the patient, addition, IgA antibody, secreted, the SARS-CoV-2, treatment for COVID-19, 【제목키워드】 Human, detection, Breast, SARS-CoV-2 RNA, persistent, report,