Abstract
Two COVID-19 mRNA (of BNT162b2, mRNA-1273) and two adenovirus vector vaccines (ChAdOx1 and Janssen) are licensed in Europe, but optimization of regime and dosing is still ongoing. Here we show in health care workers (n = 328) that two doses of BNT162b2, mRNA-1273, or a combination of ChAdOx1 adenovirus vector and mRNA vaccines administrated with a long 12-week dose interval induce equally high levels of anti-SARS-CoV-2 spike antibodies and neutralizing antibodies against D614 and Delta variant. By contrast, two doses of BNT162b2 with a short 3-week interval induce 2-3-fold lower titers of neutralizing antibodies than those from the 12-week interval, yet a third BNT162b2 or mRNA-1273 booster dose increases the antibody levels 4-fold compared to the levels after the second dose, as well as induces neutralizing antibody against Omicron BA.1 variant. Our data thus indicates that a third COVID-19 mRNA vaccine may induce cross-protective neutralizing antibodies against multiple variants.
【초록키워드】 COVID-19, neutralizing antibody, Europe, Health care, Neutralizing antibodies, antibody, mRNA vaccine, mRNA-1273, health care workers, variant, omicron, delta variant, anti-SARS-CoV-2, variants, mRNA vaccines, Adenovirus, BNT162b2, mRNA, Health care worker, antibody levels, optimization, ChAdOx1, Dosing, janssen, Combination, dose, second dose, fold, regime, mRNA-1273 booster, indicate, increase, induce, cross-protective, adenovirus vector vaccine, of BNT162b2, 【제목키워드】 COVID-19 vaccine, variant, Delta, omicron, response, Comparative analysis, booster,