Abstract
In vaccinees who were infected with SARS-CoV in 2003, we observed greater antibody responses against spike and nucleoprotein of both SARS-CoV-2 and SARS-CoV after a single dosage of inactivated SARS-CoV-2 vaccine. After receiving the second vaccination, antibodies against RBD of SARS-CoV-2 Wuhan, Beta, Delta, and recently emerged Omicron are significantly higher in SARS-CoV experienced vaccinees than in SARS-CoV naïve vaccinees. Neutralizing activities measured by authentic viruses and pseudoviruses of SARS-CoV, SARS-CoV-2 Wuhan, Beta, and Delta are greater in SARS-CoV experienced vaccinees. In contrast, only weak neutralizing activities against SARS-CoV-2 and variants were detected in SARS-CoV naïve vaccinees. By 6 months after the second vaccination, neutralizing activities were maintained at a relatively higher level in SARS-CoV experienced vaccinees but were undetectable in SARS-CoV naïve vaccinees. These findings suggested a great possibility of developing a universal vaccine by heterologous vaccination using spike antigens from different SARS-related coronaviruses.
Keywords: SARS-CoV; SARS-CoV-2; heterologous immunization; inactivated vaccine; universal vaccine.
【저자키워드】 SARS-CoV-2, SARS-CoV, Inactivated vaccine, heterologous immunization, universal vaccine., 【초록키워드】 viruses, Vaccine, vaccination, antibody, Antibody Response, variant, Delta, omicron, variants, SARS-CoV-2 vaccine, Antigen, activity, Neutralizing activity, Inactivated vaccine, Wuhan, Beta, nucleoprotein, Heterologous, inactivated, heterologous immunization, pseudoviruses, second vaccination, dosage, neutralizing activities, SARS-related coronaviruses, vaccinees, naïve vaccinees, RBD of SARS-CoV-2, vaccinee, greater, were infected, virus, receiving, suggested, significantly higher, pseudovirus, undetectable, 【제목키워드】 vaccination, Antibody Response, inactivated, individual, SARS-CoV infection,