Abstract
Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.
Keywords: COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination.
All Keywords
【저자키워드】 SARS-CoV-2, vaccination., COVID-19 variants, T-cell responses to coronavirus, 【초록키워드】 COVID-19, coronavirus disease, antibodies, Coronavirus disease 2019, coronavirus, vaccination, Mutation, T cells, T-cell Response, variant, severe acute respiratory syndrome Coronavirus, variants, T cell, B.1.1.7, vaccine response, response, Alpha, respiratory, Critical, seronegative, T-cell responses, Donor, Evidence, strain, reference strain, acute respiratory syndrome, acute respiratory syndrome coronavirus, variant spike, evaluated, to define, 【제목키워드】 vaccination, spike-specific T-cell response, mutant strain, robust, elicit,
【저자키워드】 SARS-CoV-2, vaccination., COVID-19 variants, T-cell responses to coronavirus, 【초록키워드】 COVID-19, coronavirus disease, antibodies, Coronavirus disease 2019, coronavirus, vaccination, Mutation, T cells, T-cell Response, variant, severe acute respiratory syndrome Coronavirus, variants, T cell, B.1.1.7, vaccine response, response, Alpha, respiratory, Critical, seronegative, T-cell responses, Donor, Evidence, strain, reference strain, acute respiratory syndrome, acute respiratory syndrome coronavirus, variant spike, evaluated, to define, 【제목키워드】 vaccination, spike-specific T-cell response, mutant strain, robust, elicit,
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코로나바이러스 2019 백신 반응을 설명하는 대부분의 연구는 항체에 초점을 맞추었지만 T 세포가 중요한 역할을 한다는 증거가 증가하고 있습니다. 여기에서 저자들은 중증 급성 호흡기 증후군 코로나바이러스 2 참조 균주와 변이 균주 Alpha/B.1.1.7 및 Beta/B.1.351의 돌연변이에 대한 반응을 정의하기 위해 백신 접종 전후에 혈청음성 기증자의 T 세포 반응을 평가했습니다. . 저자는 백신 접종 후 참조 및 변이 스파이크 균주에 대한 향상된 T 세포 반응을 관찰했습니다.
{{ 키워드: }} 코로나19 변종; 사스 코로나바이러스 2; 코로나바이러스에 대한 T 세포 반응; 백신 접종.