Abstract
Background: Convalescent plasma containing high levels of SARS-CoV-2 antibodies has been studied as a possible treatment for COVID-19. Better understanding of predictors of high antibody levels is needed for improving supply of high-quality therapeutic plasma.
Aims: We have evaluated demographic and clinical factors associated with the probability of a convalescent plasma donor having high SARS-CoV-2 IgG antibody levels.
Methods: A total of 29,585 convalescent plasma donors employed during the first and second waves of the COVID-19 pandemic in England were included in this study. All had been tested for SARS-CoV-2 IgG antibodies by EUROimmun ELISA. A multivariable logistic regression model was used to quantify the association of the demographic and clinical factors with high (EUROimmun S/Co>6.0) SARS-CoV-2 IgG antibody level.
Results: Most of the donors were male (23,024; 78%), with white ethnic background (24,598;83%) and had not been tested for SARS-CoV-2 (15,266; 52%).Overall, less than 20% of convalescent plasma donors with confirmed or suspected SARS-CoV-2 infection harboured high SARS-CoV-2 antibody levels (n = 4,978). We found that older male donors who had been hospitalised with COVID-19 were most likely to harbour high levels of antibodies. White donors were less likely to have high SARS-CoV-2 antibody levels than donors with Asian orblack ethnic backgrounds residing in affluent areas likely reflecting ethnic inequality previously associated with SARS-CoV-2 infection.
Discussion: In a time of great uncertainty, and predicted new waves associated with newly emerging SARS-CoV-2 variants, these results will help us to target future convalescent plasma collections.
Keywords: COVID-19; SARS-CoV-2 infection; antibody level; convalescent plasma.
【저자키워드】 COVID-19, SARS-COV-2 infection, antibody level, convalescent plasma., 【초록키워드】 convalescent plasma, SARS-CoV-2, antibody, SARS-COV-2 infection, COVID-19 pandemic, ELISA, Probability, SARS-CoV-2 antibodies, IgG antibody, SARS-CoV-2 antibody, SARS-CoV-2 variants, IgG antibodies, SARS-CoV-2 IgG antibody, therapeutic, male, plasma, second wave, antibody levels, donors, predictor, England, SARS-CoV-2 IgG, Donor, association, Asian, Older, multivariable logistic regression, SARS-CoV-2 IgG antibodies, help, white, supply, multivariable logistic regression model, MOST, levels of antibodies, hospitalised, tested, predicted, was used, evaluated, less, Better, clinical factor, treatment for COVID-19, with COVID-19, 【제목키워드】 plasma, titre, demographic factor, high neutralising antibody,