Abstract
The duration of antibody persistence following natural infection is unclear. We examined routine SARS-CoV-2 diagnostic and serological testing data on 6522 persons diagnosed between March 2020 and March 2021 who had at least 1 antibody test ≥30 days after diagnosis at CityMD, an urgent care provider. Using survival analysis, we estimated the median duration of detectable anti-SARS-CoV-2 antibodies and hazard of seroreversion by demographic and clinical characteristics. We found that over 90% (95% CI: 91.8%, 94.8%) of the study population had detectable levels of antibodies at 180 days post diagnosis and that SARS-CoV-2 antibodies persisted at a detectable level for a median duration of 342 days following infection (95% CI: 328, 361). Additionally, there were differences in antibody persistence by age, with older patients less likely to serorevert compared to younger patients. These findings suggest that protection from natural infection may wane with time and differ by demographic factors.
Keywords: COVID-19; SARS-CoV-2; antibody; persistence; survival analysis.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, survival analysis., persistence, 【초록키워드】 Clinical characteristics, antibody, Infection, diagnostic, Diagnosis, older patient, SARS-CoV-2 antibodies, survival, SARS-CoV-2 antibody, Serological testing, age, Antibody test, natural infection, Care, Analysis, survival analysis, older patients, care provider, 95% CI, study population, younger patients, hazard, demographic and clinical characteristics, Demographic factors, seroreversion, detectable anti-SARS-CoV-2 antibodies, examined, detectable, diagnosed, median, less, detectable anti-SARS-CoV-2 antibody, levels of antibody, the median, 【제목키워드】 SARS-CoV-2 antibody, Patient, New York, Care, Presence,