Abstract
Background: There is a paucity of data on the prevalence, adequate timing, and outcome of solid organ transplantation after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and the kinetics of immunoglobulin G (IgG) antibodies in these patients.
Methods: SARS-CoV-2 antinucleocapsid (N) IgG and polymerase chain reaction via a nasopharyngeal swab were analyzed in all patients within 24 h before liver or kidney transplantation. Kinetics of IgG antibodies were analyzed and compared with an immunocompetent cohort.
Results: Between May 1, 2020, and March 18, 2021, 168 patients underwent liver or kidney transplantation in our center, of which 11 (6.54%) patients with a previous SARS-CoV-2 infection were identified. The median interval between SARS-CoV-2 infection and transplantation was 4.5 mo (range, 0.9-11). After a median posttransplant follow-up of 4.9 mo, 10 out of 11 patients were alive without clinical signs of viral shedding or recurrent or active infection. One patient without symptom resolution at time of transplantation died after combined liver-kidney transplantation. In 9 out of 11 patients with previously polymerase chain reaction-confirmed infection, SARS-CoV-2 anti-N and antispike (S) IgG were detectable at day of transplantation. Absolute levels of anti-N and anti-S IgG were positively correlated, declined over time in all patients, and were significantly lower compared with immunocompetent individuals. All patients remained anti-S IgG positive until the last posttransplant follow-up, whereas 3 patients became anti-N negative.
Conclusions: We observed an uncomplicated course of liver or kidney transplantation after SARS-CoV-2 infection in selected patients. Although having lower absolute IgG antibody levels than immunocompetent individuals, all seroconverted patients remained anti-S IgG positive. These encouraging data need validation in larger studies.
【초록키워드】 SARS-CoV-2, IgG, antibody, SARS-COV-2 infection, Infection, viral shedding, solid organ transplantation, outcome, severe acute respiratory syndrome Coronavirus, kidney, Prevalence, Severe acute respiratory syndrome, Nasopharyngeal swab, polymerase chain reaction, Kinetics, Cohort, Immunoglobulin G, IgG antibody, Viral, Immunoglobulin, IgG antibodies, Patient, Clinical signs, Follow-up, respiratory, liver, patients, anti-S IgG, Coronavirus-2, organ transplantation, solid organ, transplantation, paucity of data, Chain Reaction, absolute levels, acute respiratory syndrome, acute respiratory syndrome coronavirus, one patient, acute respiratory syndrome coronavirus-2, symptom resolution, median interval, positive, significantly lower, Clinical sign, polymerase chain, Course, selected, analyzed, died, remained, detectable, median, individuals, declined, Absolute level, positively correlated, seroconverted patient, 【제목키워드】 SARS-CoV-2, IgG,