Abstract
The genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been emerging and circulating in different parts of the world from the beginning of the coronavirus disease (COVID-19) pandemic. Variants are divided into three classes: variant of interest, variant of concern, and variant of high consequence depending on its impact on the transmission, disease severity, diagnostics, vaccines, and therapeutics. The variants of concern include the United Kingdom variant (B.1.1.7), South Africa variant (B.1.351), two related California variants (B.1.427 and B.1.429), and Brazil variant (P.1). These SARS-CoV-2 variants have a direct impact on the available COVID-19 vaccines and immunotherapeutics as they can alter the neutralizing activity of vaccine-elicited antibodies and monoclonal antibodies resulting in mild-to-substantial loss of efficacy. There is a need to establish surveillance systems that can monitor the emergence of novel SARS-CoV-2 variants worldwide.
Keywords: COVID-19; SARS-CoV-2; neutralizing antibodies; vaccine efficacy; variant of concern; variants.
【저자키워드】 COVID-19, SARS-CoV-2, Neutralizing antibodies, vaccine efficacy, variants, variant of concern, 【초록키워드】 coronavirus disease, Brazil, Efficacy, Vaccine, coronavirus, COVID-19 vaccine, pandemic, Vaccines, Neutralizing antibodies, antibody, Therapeutics, B.1.351, disease severity, monoclonal antibody, variant, SARS-CoV-2 variant, vaccine efficacy, variants of concern, Transmission, severe acute respiratory syndrome Coronavirus, monoclonal antibodies, diagnostics, variants, Neutralizing activity, South Africa, Surveillance, SARS-CoV-2 variants, B.1.427, B.1.1.7, P.1, B.1.429, Neutralizing, genetic variants, Genetic variant, respiratory, United Kingdom, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, circulating, MONITOR, Alter, resulting, include, 【제목키워드】 neutralizing antibody, Efficacy, Vaccine,