Abstract
The aim was to measure neutralizing antibody levels against the SARS-CoV-2 Omicron (BA.1) variant in serum samples obtained from vaccinated PLWH and healthcare workers (HCW) and compare them with those against the Wuhan-D614G (W-D614G) strain, before and after the third dose of a mRNA vaccine. We included 106 PLWH and 28 HCWs, for a total of 134 participants. Before the third dose, the proportion of participants with undetectable nAbsT against BA.1 was 88% in the PLWH low CD4 nadir group, 80% in the high nadir group and 100% in the HCW. Before the third dose, the proportion of participants with detectable nAbsT against BA.1 was 12% in the PLWH low nadir group, 20% in the high nadir group and 0% in HCW, respectively. After 2 weeks from the third dose, 89% of the PLWH in the low nadir group, 100% in the high nadir group and 96% of HCW elicited detectable nAbsT against BA.1. After the third dose, the mean log2 nAbsT against BA.1 in the HCW and PLWH with a high nadir group was lower than that seen against W-D614G (6.1 log2 (±1.8) vs. 7.9 (±1.1) and 6.4 (±1.3) vs. 8.6 (±0.8)), respectively. We found no evidence of a different level of nAbsT neutralization by BA.1 vs. W-D614G between PLWH with a high CD4 nadir and HCW (0.40 (-1.64, 2.43); p = 0.703). Interestingly, in PLWH with a low CD4 nadir, the mean log2 difference between nAbsT against BA.1 and W-D614G was smaller in those with current CD4 counts 201-500 vs. those with CD4 counts < 200 cells/mm 3 (-0.80 (-1.52, -0.08); p = 0.029), suggesting that in this target population with a low CD4 nadir, current CD4 count might play a role in diversifying the level of SARS-CoV-2 neutralization.
Keywords: HIV/AIDS; Omicron variant; SARS-CoV-2; SARS-CoV-2 vaccine; neutralization titers; third dose vaccine.
【저자키워드】 SARS-CoV-2, HIV/AIDS, SARS-CoV-2 vaccine, Omicron variant, neutralization titers, third dose vaccine., 【초록키워드】 neutralizing antibody, HIV/AIDS, Vaccine, Healthcare workers, mRNA vaccine, neutralization, variant, omicron, CD4, healthcare worker, SARS-CoV-2 vaccine, HCWs, AIDS, Omicron variant, PLWH, SARS-CoV-2 neutralization, neutralization titers, Evidence, dose, HCW, evidence of, no evidence of, target population, Participants, serum samples, participant, CD4 counts, serum sample, proportion, detectable, elicited, the mean, CD4 count, the SARS-CoV-2, undetectable, 【제목키워드】 omicron,