Abstract
In Japan, healthcare workers (HCWs) are vaccinated against measles, rubella, chickenpox, mumps, and hepatitis B to prevent nosocomial infection; however, some do not produce sufficient antibodies (“suboptimal responders”). This study compared immune responses to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 mRNA) vaccine among HCWs with normal and suboptimal responses to conventional vaccines. In this prospective cohort study, 50 HCWs received two doses of BNT162b2 mRNA vaccine 3 weeks apart. SARS-CoV-2 anti-spike antibodies were measured 11 times, starting before the first vaccination and ending 5 months after the second vaccination. Antibody titers of four suboptimal and 46 normal responders were compared. SARS-CoV-2 neutralizing antibody activity was measured twice in suboptimal responders, 1 week/1 month and 5 months after the second vaccination. The SARS-CoV-2 anti-spike antibody was detectable in the samples from suboptimal and normal responders at each timepoint after vaccination. Suboptimal responders exhibited SARS-CoV-2 neutralizing antibody activity 1 week/1 month as well as 5 months after the second vaccination; however, activity was slightly reduced at 5 months. Our findings show that suboptimal responders do acquire adequate SARS-CoV-2 anti-spike and SARS-CoV-2 neutralizing antibodies from vaccination to prevent SARS-CoV-2. SARS-CoV-2 mRNA vaccines should thus be recommended for both normal and suboptimal responders to conventional vaccines.
Keywords: anti-spike antibody; coronavirus disease 2019; mRNA vaccine; neutralizing antibody; severe acute respiratory syndrome coronavirus 2.
【저자키워드】 neutralizing antibody, Coronavirus disease 2019, mRNA vaccine, Severe acute respiratory syndrome coronavirus 2., anti-spike antibody, 【초록키워드】 coronavirus disease, neutralizing antibody, SARS-CoV-2, Coronavirus disease 2019, Vaccine, coronavirus, immune response, vaccination, Healthcare workers, antibody, mRNA vaccine, nosocomial, prospective cohort study, severe acute respiratory syndrome Coronavirus, healthcare worker, BNT162b2, HCWs, mRNA, immune responses, response, Nosocomial infection, Japan, hepatitis B, Neutralizing, Responder, respiratory, SARS-CoV-2 neutralizing antibodies, anti-spike antibodies, Antibody titers, Anti-spike, SARS-CoV-2 neutralizing antibody, BNT162b2 mRNA vaccine, anti-spike antibody, measles, dose, mumps, rubella, HCW, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, second vaccination, responders, first vaccination, Chickenpox, Prevent, conventional vaccines, was measured, detectable, reduced, exhibited, were measured, of BNT162b2, 【제목키워드】 SARS-CoV-2, mRNA, response, individual, Adequate, Can, Conventional,