Abstract
This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
Keywords: COVID-19; SARS-CoV-2; blood-brain barrier; intrathecal synthesis; neurological manifestations.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, blood-brain barrier, neurological manifestations, intrathecal synthesis, 【초록키워드】 coronavirus disease, IgG, Coronavirus disease 2019, coronavirus, RNA, Immunoglobulin G, Immunoglobulin, Patient, blood-brain barrier, neurological manifestations, Neurological complications, cerebrospinal fluid, respiratory, Neuropathogenesis, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, feature, observé, analyzed, 【제목키워드】 RT-PCR, coronavirus 2, reaction, chain,
【저자키워드】 COVID-19, SARS-CoV-2, blood-brain barrier, neurological manifestations, intrathecal synthesis, 【초록키워드】 coronavirus disease, IgG, Coronavirus disease 2019, coronavirus, RNA, Immunoglobulin G, Immunoglobulin, Patient, blood-brain barrier, neurological manifestations, Neurological complications, cerebrospinal fluid, respiratory, Neuropathogenesis, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, feature, observé, analyzed, 【제목키워드】 RT-PCR, coronavirus 2, reaction, chain,
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이 연구는 신경학적 합병증이 있는 2019 코로나바이러스감염증-19(COVID-19) 환자 31명의 뇌척수액 특징을 분석했습니다. 우리는 뇌척수액에서 중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) RNA나 척수강내 면역글로불린 G(IgG) 합성을 관찰하지 않았지만 혈액-뇌 장벽 파괴의 징후를 관찰했습니다. 이러한 결과는 SARS-CoV-2 관련 신경병증 발생에 대한 더 나은 이해를 위한 기초가 될 수 있습니다.
{{ 키워드: }} 코로나19; 사스 코로나바이러스 2; 혈액뇌장벽; 경막내 합성; 신경계 증상.