Abstract
Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is important. The spike protein is the most immunogenic component of the virus. Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. Neutralizing antibodies are generated by the humoral immune system and reduce the viral load by binding to spike protein components. Neutralizing antibodies are the proteins secreted by plasma cells and serve as an important part of the defense mechanism. In the recent Covid-19 infection, neutralizing antibodies can be utilized for both diagnostic such as immune surveillance and therapeutic tools such as plasma therapy. So far, many monoclonal antibodies are in the clinical trial phase, and few of them are already in use. In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease.
Keywords: Angiotensin converting enzyme-2 (ACE2) receptor; Convalescent plasma transfer (CPT); Covid-19; Neutralizing antibody; Receptor-binding domain (RBD).
【저자키워드】 COVID-19, neutralizing antibody, Angiotensin converting enzyme-2 (ACE2) receptor, Convalescent plasma transfer (CPT), Receptor-binding domain (RBD)., 【초록키워드】 neutralizing antibody, ACE2, Vaccine development, coronavirus, clinical trial, pandemic, therapy, Infectious diseases, Neutralizing antibodies, antibody, monoclonal antibody, Infection, diagnostic, Infectious disease, immune system, monoclonal antibodies, virus, plasma therapy, immune, Spike protein, COVID-19 disease, Protein, Health, Viral, Receptor-binding domain, Surveillance, COVID-19 infection, Viral load, outbreak, RBD, therapeutic, Community, plasma, WHO, receptor, disease, mechanism, Plasma cell, binding, Plasma cells, community health, angiotensin, humoral, life, Health Organization, immune surveillance, World Health Organization, defense mechanism, enzyme, components, transfer, immunogenic, human lung cells, Defense, MOST, combating, shown, recognize, the spike protein, interact, the receptor-binding domain, reduce, secreted, 【제목키워드】 disease,