Abstract
Autoimmunity, hyperstimulation of the immune system, can be caused by a variety of reasons. Viruses are thought to be important environmental elements that contribute to the development of autoimmune antibodies. It seems that viruses cause autoimmunity with mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation, which has also been seen in post-Covid-19 autoimmunity. Infection of respiratory epithelium by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates the immune response, triggers both innate and acquired immunity that led to the immune system’s hyperactivation, excessive cytokine secretion known as “cytokine storm,” and finally acute respiratory distress syndrome (ARDS) associated with high mortality. Any factor in the body that triggers chronic inflammation can contribute to autoimmune disease, which has been documented during the Covid-19 pandemic. It has been observed that some patients produce autoantibody and autoreactive CD4 + and CD8 + T cells, leading to the loss of self-tolerance. However, there is a scarcity of evidence defining the precise molecular interaction between the virus and the immune system to elicit autoreactivity. Here, we present a review of the relevant immunological findings in Covid-19 and the current reports of autoimmune disease associated with the disease.
Keywords: Autoimmune disease; Autoimmunity; Covid-19; Cytokine; SARS-CoV-2.
【저자키워드】 COVID-19, Autoimmunity, cytokine, SARS-CoV-2., Autoimmune disease, 【초록키워드】 viruses, SARS-CoV-2, Inflammation, Autoimmunity, Respiratory distress syndrome, ARDS, Cytokine storm, coronavirus, immune response, pandemic, acute respiratory distress syndrome, Immunity, T cells, COVID-19 pandemic, Immunosuppression, cytokine, immune system, severe acute respiratory syndrome Coronavirus, virus, CD4, CD8, Autoimmune disease, Patient, chronic inflammation, molecular, molecular mimicry, acquired immunity, respiratory, mechanism, autoreactivity, acute respiratory distress, Evidence, scarcity, Trigger, autoantibody, Hyperstimulation, triggers, respiratory distress, autoimmune antibodies, bystander, acute respiratory syndrome, Activation, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, syndrome, high mortality, molecular interaction, Hyperactivation, respiratory epithelium, element, self-tolerance, cytokine secretion, immunological, thought, caused, virus, the disease, contribute, variety, elicit, 【제목키워드】 SARS-CoV-2, triggering,